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Ester zymoid method production process of azeotropy water elimination coupling simulated moving bed

A technology that simulates moving beds and production processes. It is used in chemical recovery, fermentation, etc., and can solve problems such as low efficiency and high cost.

Active Publication Date: 2009-05-13
南京宏瑞药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product is separated from the mixture to obtain a product with a purity of more than 95%, which is extremely inefficient and expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0013] 26g of palmitic acid, 17g of L-ascorbic acid and 1g of Novozym 435 were added to 100ml of anhydrous tert-amyl alcohol to form a mixture, then reacted at 55°C for 8hr under constant stirring. Then add 10ml of cyclohexane, turn on the vacuum pump, and reduce the pressure of the reaction system to 0.001-0.005MPa, so that the azeotropic mixed steam is evaporated, and the steamed mixed steam is condensed and separated into layers to form a cyclohexane phase and an aqueous phase , the cyclohexane phase automatically returns to the reaction system for recycling. The reaction system continued to maintain the reaction while evaporating, condensing, and refluxing in this state until all the ascorbic acid solids disappeared in the reaction system, and the volume of the water phase in the water-splitting condenser no longer increased, and continued to maintain the reaction for 4hr.

[0014] After the reaction, the reaction mixture was filtered to separate the solid enzyme, and then...

example 2

[0018] 22g of lauric acid, 17g of shikimic acid and 1g of Aspergillus niger-derived lipase were added to 100ml of anhydrous tert-butanol to form a mixture, and then reacted at 36°C for 12hr under constant stirring. Then add 10ml of pentane, turn on the vacuum pump, reduce the pressure of the reaction system to 0.01-0.005MPa, so that the azeotropic mixed steam is evaporated, and the steamed mixed steam is condensed and separated to form a pentane phase and an aqueous phase. The alkane phase automatically returns to the reaction system for recycling. The reaction system continued to maintain the reaction while evaporating, condensing, and refluxing in this state until all the shikimic acid solids disappeared in the reaction system, and the volume of the water phase in the water-splitting condenser did not increase any more, and the reaction was continued for 4 hours.

[0019] After the reaction was finished, the reaction mixture was filtered to separate the solid enzyme, and the...

example 3

[0023] 26 palmitic acid, 17 g shikimic acid and 1 g Aspergillus niger-derived lipase were added to 100 ml of anhydrous tert-butanol to form a mixture, and then reacted at 36° C. for 12 hr under constant stirring. Then add 10ml of hexane, turn on the vacuum pump, reduce the pressure of the reaction system to 0.001-0.005MPa, so that the azeotropic mixed steam is evaporated, and the steamed mixed steam is condensed and separated into layers to form a hexane phase and a water phase. The alkane phase automatically returns to the reaction system for recycling. The reaction system continued to maintain the reaction while evaporating, condensing, and refluxing in this state until all the shikimic acid solids disappeared in the reaction system, and the volume of the water phase in the water-splitting condenser did not increase any more, and the reaction was continued for 4 hours.

[0024]After the reaction is finished, the reaction mixture is filtered to separate the solid enzyme, and ...

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Abstract

The invention belongs to the biotechnology field of non-aqueous phase enzymatic organic synthesis application, and particularly relates to an ester enzyme method production process for an azeotropic dewatering coupling simulated moving bed. The process is applied to the synthesis of various ester bonds by catalysis of a biological catalyst (such as Novozym 435). The invention provides a commonly used ester enzyme method synthesis novel process; in the premise of not affecting the catalytic activity of the biological catalyst, the process can continuously remove water by decompression azeotropy and make the reaction balance move towards the ester synthesis, thereby greatly improving the conversion rate of the enzymatic organic synthesis, ensuring the complete reaction and thoroughly solving the continuous dewatering problem in the non-aqueous phase enzymatic organic synthesis; by the coupling of the enzymatic reaction system and the simulated moving bed chromatographic separation system, the process can ensure the complete separation of reaction products and excessive reaction materials, solve the problem of recycling the excessive reaction materials, improve the conversion rate of raw materials, the product yield and the product purity to be nearly 100 percent, greatly lower production cost, realize the zero emission of waste water and waste residue during the production of ester chemical products and has wide application prospect in fields such as medicine, food, material, fine chemical industry.

Description

technical field [0001] The invention belongs to the field of applied biotechnology of non-aqueous phase enzymatic organic synthesis, in particular to an ester enzymatic production process of azeotropic water removal coupled with a simulated moving bed. Background technique [0002] Regarding the synthesis of esters, there are two types of methods: chemical synthesis and biocatalytic synthesis. The chemical synthesis process is very mature and is still widely used in the industrial production of organic esters. But there are some fatal flaws in the chemical synthesis process. This process often requires the use of strong liquid acids such as concentrated sulfuric acid or p-methoxybenzenesulfonic acid as a catalyst, and the reaction temperature is very high, usually accompanied by unavoidable side reactions, which have a great impact on the conversion rate of raw materials and the yield of products. Large, the separation and purification process is complicated, and it also h...

Claims

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Application Information

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IPC IPC(8): C12P7/62C12P7/64
CPCY02P20/582
Inventor 汤鲁宏孙阳王择戴阿娟邓超陈伟徐玲燕
Owner 南京宏瑞药业有限公司
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