Pharmaceutical composition for treating leukaemia

A composition and drug technology, applied in the field of medicine, can solve problems such as toxic and side effects

Inactive Publication Date: 2009-06-03
TIANJIN JINGUIGU XYLITOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the patient is weak, malnourished, and has undergone multiple long-term chemotherapy or after the condition is in remission, severe toxic side effects will occur if the chemotherapy drug is continued

Method used

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  • Pharmaceutical composition for treating leukaemia

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 10 parts of anhydrous dulcitol, 30 parts of angelica, 30 parts of astragalus, 15 parts of ginseng, 15 parts of salvia miltiorrhiza, 15 parts of codonopsis, 10 parts of yuanshen, (heating or percolation) 2 times, combined 2 extracts, decompressed The ethanol was recovered to obtain a crude extract, and the dregs were discarded. The crude extract is adjusted to pH 7-8 with 5% NaOH solution to obtain an alkaline liquid, which is extracted with chloroform (or petroleum ether). Separate the solvent layer, discard it, adjust the pH of the water layer to 2-4 with 5% sulfuric acid, place it, centrifuge, and acidify the precipitate for later use. After drying, 30g (C) is obtained, and the solution is extracted with chloroform (or petroleum ether). The layers were separated, the water layer was concentrated to obtain 86g, and the solvent layer was concentrated to obtain an extract, which was dried to obtain 40g of (D), which was uniformly mixed with the acidic precipitate to obta...

Embodiment 2

[0038] Mix 30 parts of angelica, 30 parts of astragalus, 15 parts of ginseng, 15 parts of salvia miltiorrhiza, 15 parts of codonopsis pilosula, and 10 parts of yuanshen, extract twice with 18 times the amount of 50% ethanol, combine the two extracts, recover ethanol under reduced pressure, and obtain crude Extract, dregs discarded. Adjust the pH of the crude extract to 7-8 with 5% NaOH solution to obtain an alkaline liquid, filter, discard the precipitate, adjust the pH of the supernatant to 2-4 with 5% sulfuric acid, place it, centrifuge, and acidify Standby, after drying, 34g was obtained. The solution was extracted with ethyl acetate (or n-butanol), separated into layers, the water layer was discarded, and the solvent layer was concentrated to obtain the extract, which was dried to obtain 45g, and mixed with the acidic precipitate to obtain a mixture of 79g. The extract and 10 parts of dehydrodulcitol are uniformly mixed, 20 parts of starch and 5 parts of magnesium stearate...

Embodiment 3

[0040] 80 parts of anhydrous dulcitol, 50 parts of astragalus, 50 parts of ginseng, 50 parts of salvia miltiorrhiza, 50 parts of codonopsis, 30 parts of yuan ginseng, mixed with 18 times the amount of 1% sodium hydroxide (or sodium carbonate) solution to extract 2 times, the two extracts were combined, concentrated under reduced pressure to obtain a crude extract, and the dregs were discarded. The crude extract was applied to a silica gel column, eluted with chloroform (or ethyl acetate, methanol), and each fraction was collected for qualitative identification with magnesium powder-hydrochloric acid. The positive fractions were combined and concentrated under reduced pressure to obtain 30 g of the mixture. Mix the extract and 10 parts of dulcitol evenly, add No. 2 capsules, and make capsules.

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Abstract

The invention discloses a pharmaceutical composition for treating leukaemia. The composition is made from the following raw materials: 10-50 parts of anhydrogalactitol, 30-50 parts of angelica, 30-50 parts of astragalus root, 15-50 parts of ginseng, 15-50 parts of red sage root, 15-50 parts of pilose asiabell root and 10-30 parts of figwirt root. The pharmaceutical composition has obvious effects on treating the leukaemia, certain curative effect on lung cancer, multiple myeloma, nasopharyngeal carcinoma and the like, especially good short-term curative effect on chronic granulocytic leukemia with a remission rate up to 86%, higher effective rate on various lung cancers and less toxic side effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition containing dulcitol for treating leukemia. Background technique [0002] Leukemia is a malignant disease of the hematopoietic system, characterized by extensive and uncontrolled proliferation of a large number of leukemia cells in the body, appearing in the bone marrow and many other organs and tissues, and entering the peripheral blood. Acute leukemia is characterized by rapid onset, rapid progress, and dangerous condition, which seriously endangers human health. With the advancement of medicine, most patients with acute leukemia can achieve remission after active treatment. Now remission of leukemia is no longer the ultimate goal of treatment. How to improve the cure rate so that most leukemia patients can be cured has become the focus of current hematology research . [0003] Chronic myelogenous leukemia is a kind of leukemia with relatively slo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61P35/02A61K31/047
Inventor 马永华邱洪江
Owner TIANJIN JINGUIGU XYLITOL
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