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Anthelmintic agent and preparation method thereof

A technology of anthelmintic medicine and raw material medicine, which is applied in the direction of medical formula, drug combination, anti-infective medicine, etc. It can solve the problems of increased dosage of sweeteners for pharmaceutical excipients, difficulty in appending to diabetics, poor deworming effect, etc.

Inactive Publication Date: 2009-06-10
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing niclosamide preparations all have the problem of poor anthelmintic effect
It is necessary to use a relatively large dose of niclosamide to achieve the purpose of deworming, and the corresponding dosage of the used medicinal auxiliary sweetener will also increase, thus bringing difficulties to the dependents of diabetic patients. The present invention This issue has been resolved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Propylene Glycol / Glycerin Niclosamide Sodium Arginate

[0017] Under stirring, 0.5 g of ground (ie powdered) NaOH and 0.1 g of ground sodium metabisulfite were dissolved in 100 ml of propylene glycol. It is necessary to warm the propylene glycol slightly to aid in the dissolution of these substances. With stirring, 4 g of powdered (through 80 mesh) anhydrous niclosamide sodium arginine were slowly added until dissolved to form a 4% (g niclosamide sodium arginine / 100 ml propylene glycol ) solution. Further 1 g of xylitol was added, and the resulting solution was filtered and filled into a sealed bottle. Care was taken not to bring water into the solution as this could lead to deterioration of the final product as evidenced by a brownish-yellow turn from the originally clear solution. The solution was tested by initially testing the 4% solution on lambs against tapeworm and trypanosome infection. The results show that small amounts of niclosamide sodium arginate accor...

Embodiment 2

[0019] Oral administration of sodium arginine preparation of niclosamide against lambs naturally infected with Taenia monnieri ( Moniezia exDansa) Evaluation of the role

[0020] Under various doses, measure 4% niclosamide sodium arginine ("test product") of the present invention prepared by the method of Example 1 and 20% (g niclosamide / 100ml carrier) obtained through commercial channels Efficacy of a formulation of niclosamide in suspension ("Standard") in the control of Taenia monnieri. Standards were administered at the indicated doses of 40 or 50 mg / kg. The trial was conducted on the applicant's farm. Measurements and identification of Taenia monnyi diet and staining were carried out in the laboratory. Approximately 2 month old Dorper sheep were used in this experiment. During the experiment, the sheep were penned in livestock pens and fed alfalfa and tap water.

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PUM

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Abstract

The invention relates to anthelmintic and preparing method thereof, the anthelmintic comprises sodium arginine containing pharmaceutical xylitol and niclosamide and mixture containing propylene glycol and glycerin. The anthelmintic has effective helminth-expelling action, can be used as anthelmintic for veterinarian or human, the anthelmintic can be administrated by the forms of liquid or in the capsule or by forms of granular formulation or tablet prepared by the solution. The administration dose such as 15 mg / kg body weight can be easily determined according to the practical situation.

Description

technical field [0001] The present invention relates to anthelmintic medicine. In particular it relates to anthelmintics containing the active ingredient niclosamide sodium arginine. Background technique [0002] Niclosamide (2',5-dichloro-4'-nitrosalicylanilide) is a known anthelmintic sold by Bayer (Pty) Ltd. under the tradename "Lintex". Known solutions of niclosamide exist in the form of suspensions in liquid media of niclosamide. Typically, 20% (g niclosamide / 100 ml vehicle) formulations of these suspensions are administered to animals at a dose of 1 ml per 4 kg body weight for the control of tapeworm and / or trypanosome infection. However, the existing niclosamide preparations all have the problem of poor anthelmintic effect. It is necessary to use a relatively large dose of niclosamide to achieve the purpose of deworming, and the corresponding dosage of the used medicinal auxiliary sweetener will also increase, thus bringing difficulties to the dependents of diabeti...

Claims

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Application Information

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IPC IPC(8): A61K31/609A61K47/10A61P33/14A61P33/02A61K33/14
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA