Scullcap total-flavonoid aglycone extract, preparation method and use thereof

A total flavonoid aglycone and extract technology, applied in the field of medicine, can solve the problems of hidden danger of clinical drug use, high cost, and it is difficult to tell whether it is a glycoside or aglycone, etc., and achieves the improvement of renal function damage, the process is simple, and the anti-kidney resistance is achieved. The effect of interstitial fibrosis
CN101455718AActive Publication Date: 2009-06-17SHANGHAI UNIV OF T C M
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI UNIV OF T C M
Publication Date
2009-06-17

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Abstract

The invention discloses a radix scutellariae total flavonoids aglycon extract, also a preparation method of radix scutellariae total flavonoids aglycon extract and functions of treating and resisting renal fibrosis. Content of total flavonoids aglycons in the radix scutellariae total flavonoids aglycon extract is 45-70%. The extract is mainly composed of scutellarein, wogonin, oroxylin A and other aglycons. The preparation method of the extract is as follows: crushing radix scutellariae roots, screening by a No. 1 screen; adding 1-5 times amount of water, uniformly stirring, keeping temperature for enzymolysis at 32-40 DEG C for 5-9 hours, baking under vacuum at 60 DEG C, adding 2-8 times amount of ethyl acetate, continuously extracting for 6-10 hours, depressurizing, recycling solvent, thus obtaining total flavonoids aglycon extract. The extract can obviously relieve renal fibrosis symptoms when irrigated into a mouse stomach with renal fibrosis caused by mercuric chloride moulding and when a group of mice having the extract is compared with group of mice without having the extract. Results suggest that the total flavonoids aglycon extract has a dose dependence in preventing renal fibrosis.
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Description

technical field

[0001] The invention relates to a total flavonoid aglycone extract of Scutellaria baicalensis, its preparation method and application, specifically the preparation of the main aglycone contained in Scutellaria baicalensis and its application in anti-renal fibrosis, belonging to the technical field of medicine. Background technique

[0002] Renal tissue cells are rich in metabolism, and tissue hypoxia and oxidative stress damage are prone to occur after damage. Oxidative stress can not only lead to lipid peroxidation and inflammatory damage in tissues, but also stimulate the expression of pro-fibrotic factors in renal tubular epithelial cell transdifferentiation, thereby leading to renal fibrosis; and further aggravate inflammatory damage by activating the NF-κB pathway with fibrosis. Renal fibrosis is a common pathway for the development of various chronic kidney diseases to chronic renal failure and other end-stage renal diseases, including renal interstiti...

Claims

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