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Use of baicalin in preparing medicine
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A technology of baicalin and medicine, applied to the application field of baicalin in pharmaceuticals, can solve problems such as no report on the effect of baicalin, no report on lupus erythematosus nephritis, etc.
Inactive Publication Date: 2009-07-29
ZHONGSHAN HOSPITAL FUDAN UNIV
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Embodiment 1
[0031] Embodiment 1: the extraction of baicalin
[0032] Use 2.5kg of Scutellaria baicalensis plant of Labiatae, extract twice with 95vol% ethanol at 65°C for two hours each time, concentrate the extract at 70°C under reduced pressure, cool the obtained concentrate to room temperature, centrifuge, filter, and the filtrate Concentrate under reduced pressure at 70°C, add ethanol to the obtained concentrated solution to 85vol% for alcoholprecipitation, stand and filter the alcoholprecipitation solution, take the supernatant, filter to remove impurities, concentrate under reduced pressure at 70°C, spray dry, and sterilize by ultraviolet light , to obtain baicalin.
[0034] With 300g of baicalin obtained in Example 1, add 300g polyethylene glycol (PEG-400), 30g triethanolamine, 20g hydroxypropyl-β-cyclodextrin 20g and glycerin 40g, mix and dissolve to make a solution, and use a pressure film Soft capsules are prepared by the method, the soft capsules are solidified and dried by cold air, the pills are washed with an appropriate solvent, and finally dried.
[0035] The present invention can also prepare other dosage forms by conventional methods, such as soft capsules, enteric-coated capsules, microcapsules, powders, granules, syrups, injections, suppositories, pills, gels, patches, emulsions, suspensions, solutions, etc. The formulations of the present invention may be in coated or uncoated form, as desired. Pharmaceutical excipients in the present invention include excipients, lubricants, binders, disintegrants, stabilizers, foaming agents, coating agents, etc. for solid preparations, or...
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Abstract
The invention relates to application of scutelloside in pharmacy. The scutelloside promotes a T cell to be transformed toward Treg with immunological suppression effect by up-regulating the expression of Foxp3; at the same time, the scutelloside inhibits Th17 with pro-inflammatory effect and inhibits vasculitis mediated by the Th17. A main mechanism of inhibting the Th17 of the scutelloside is to inhibit the amplification of the Th17 mediated by IL-6. At the same time, a further experiment proves that the scutelloside taken as a novel immunomodulator plays good therapeutic effect on treating lupus erythenlatosus nephritis and rheumatoid arthritis.
Description
technical field [0001] The invention relates to the new application of baicalin, in particular to the application in the preparation of medicines for preventing and treating lupus erythematosusnephritis, rheumatoid arthritis and vasculitis. Background technique [0002] Autoimmune disease is a disease mediated by immune cells that endangers human health. It is often accompanied by damage to multiple organs and systems, and in severe cases it is life-threatening. Immunosuppressants such as hormones are currently the first-line drugs for treatment, but the serious side effects often make the condition worse, and even the treatment is terminated. With changes in environmental pollution and life and work pressure, the incidence of autoimmune diseases is increasing year by year. Finding safe and effective drugs for the treatment of autoimmune diseases has become a subject of intensive research worldwide. [0003] Autoimmune diseases are often accompanied by the breakdown of im...
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