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Method for preparing ginkgo leaf extract cyclodextrin inclusion compound and preparation

A cyclodextrin inclusion compound and extract technology, which is applied in the direction of drug combination, medical raw materials derived from Ginkgo biloba, and pharmaceutical formulations, can solve the problems of low dissolution rate, poor storage performance, and poor solubility

Active Publication Date: 2009-08-12
山西振东泰盛制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a cyclodextrin inclusion compound of ginkgo leaf extract and its preparation in order to solve the problems of poor solubility, low dissolution rate and poor storage performance in various preparations of ginkgo leaf extract existing in the prior art preparation method

Method used

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  • Method for preparing ginkgo leaf extract cyclodextrin inclusion compound and preparation
  • Method for preparing ginkgo leaf extract cyclodextrin inclusion compound and preparation
  • Method for preparing ginkgo leaf extract cyclodextrin inclusion compound and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of Ginkgo Biloba Extract 2-Hydroxypropyl-β-cyclodextrin Inclusion Complex Tablets

[0036] Ginkgo biloba extract 10g

[0037] 95% ethanol 10ml

[0038] 2-Hydroxypropyl-β-cyclodextrin 20g

[0039] Starch 80g

[0040] Sodium carboxymethyl starch 10g

[0041] 10% starch paste 200g

[0042] Magnesium Stearate 5g

[0043] Take 20g of 2-hydroxypropyl-β-cyclodextrin, add 380g of water and heat to 50°C to dissolve it to make a 2-hydroxypropyl-β-cyclodextrin solution, take 10g of Ginkgo biloba extract and dissolve it in 10ml95% In ethanol, then slowly drop the ginkgo biloba extract alcohol solution into the 2-hydroxypropyl-β-cyclodextrin solution and continue stirring for 1 hour; stop heating, continue stirring for 1-3 hours, and use an electric stirring device for stirring. The rotation speed is 40-80 rev / min; the stirring is stopped, the reaction solution is left standing, filtered, and dried under reduced pressure in vacuum to obtain the inclusion complex of...

Embodiment 2

[0046] Preparation of Ginkgo Biloba Extract 2-Hydroxypropyl-β-cyclodextrin Inclusion Complex Granules

[0047] Ginkgo biloba extract 10g

[0048] 95% ethanol 10ml

[0049] 2-Hydroxypropyl-β-cyclodextrin 40g

[0050] Starch 200g

[0051] 200g powdered sugar

[0052] 20% starch paste 200g

[0053] Take 40g of 2-hydroxypropyl-β-cyclodextrin, add 360g of water and heat to 55°C to dissolve it to make a 2-hydroxypropyl-β-cyclodextrin solution, take 10g of ginkgo biloba extract and dissolve it in 10ml95% in ethanol, then slowly drop the ginkgo biloba extract ethanol solution into the 2-hydroxypropyl-β-cyclodextrin solution and stir for 1 hour; stop heating, continue stirring for 1-3 hours, and use an electric stirring device for stirring, with a speed of 40-80 rev / min; stop stirring, let the reaction solution stand still, filter, and dry under reduced pressure in vacuum to obtain the inclusion complex of ginkgo biloba extract 2-hydroxypropyl-β-cyclodextrin.

[0054] Take 10g of...

Embodiment 3

[0056] Preparation of Ginkgo Biloba Extract 2-Hydroxypropyl-β-cyclodextrin Inclusion Compound Small Volume Injection

[0057] Ginkgo biloba extract 10g

[0058] 95% ethanol 10ml

[0059] 2-Hydroxypropyl-β-cyclodextrin 30g

[0060] Thiourea 2.5g

[0061] Medicinal Charcoal 2.5g

[0062] Water for injection 2400ml

[0063] First, add 30g of 2-hydroxypropyl-β-cyclodextrin and 350g of water and heat it to 60°C to dissolve all of it to make a 2-hydroxypropyl-β-cyclodextrin solution; secondly, add 10g of Ginkgo biloba extract with 95% ethanol Dissolve 10ml, slowly drop into the 2-hydroxypropyl-β-cyclodextrin solution and stir for 1 hour; stop heating and continue stirring for 1-3 hours; stir with an electric stirring device at a speed of 40-80 rpm. Stirring was stopped and the reaction solution was left to stand for 2 hours. After reaching room temperature, take 100ml of Ginkgo biloba extract 2-hydroxypropyl-β-cyclodextrin inclusion complex and filter it with a 0.22μm filter, ...

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Abstract

The invention relates to a preparation prepared by ginkgo biloba extract, in particular to a ginkgo biloba extract cyclodextrin inclusion compound and a preparation method of the preparation. The problems of poor solubility, low dissolution rate, poor storage performance and the like in a variety of preparations of the ginkgo biloba extract in the prior art can be solved. The method comprises the steps of adding water in 2-hydroxypropyl-beta-cyclodextrin, heating and dissolving to prepare 2-hydroxypropyl-beta-cyclodextrin solution, then using 95 percent ethanol for dissolving the ginkgo biloba extract, dripping ginkgo biloba extract-ethanol solution to the 2-hydroxypropyl-beta-cyclodextrin solution under the stirring state, lasting the process for 1 hour, stopping heating after completing the dripping, continuously stirring for 1-3 hours; stopping stirring, standing reaction liquid and filtering for preparation. The ginkgo biloba extract 2-hydroxypropyl-beta-cyclodextrin inclusion compound and a variety of preparations can greatly improve the problem of small solubility of the ginkgo biloba extract in the water and improve the stability of the ginkgo biloba extract in the water.

Description

technical field [0001] The invention relates to a preparation prepared from ginkgo leaf extract, in particular to a ginkgo leaf extract cyclodextrin inclusion compound and a preparation method of the preparation. Background technique [0002] Ginkgo biloba contains a large amount of active ingredients such as ginkgo flavonoids and ginkgo terpene lactones, which can improve human breathing and sleep quality. Long-term use can prevent and treat cardiovascular diseases. Prevent high blood pressure, stroke, Diabetes and other natural substances that can enable adults to maintain normal cardiac output and normal nervous system functions, especially in middle-aged and old age, so that people can maintain a normal cell life cycle as much as possible. [0003] Modern studies have found that flavonoids in Ginkgo biloba extract have good effects on improving heart and brain blood circulation, lowering serum cholesterol, and relaxing bronchial smooth muscle. , increase cerebral blood ...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K47/48A61P9/00A61P9/12A61P9/10A61P7/02A61P3/10A61K127/00A61K47/69
Inventor 刘近荣韩雪锋沈达
Owner 山西振东泰盛制药有限公司
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