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A method for preparing radiation graft copolymer of polylactic acid and N-vinyl pyrrolidone

A technology of vinylpyrrolidone and radiation grafting, applied in the field of biomedical materials, can solve the problems of complex purification process of graft copolymers, difficult control of graft ratio of graft copolymers, complex reaction process, etc.

Active Publication Date: 2010-09-29
SICHUAN INST OF ATOMIC ENERGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Obviously, the above two synthetic methods are chemical polymerization methods, which have the disadvantages of complex reaction process, low molecular weight of graft copolymer, difficult control of graft ratio of graft copolymer and complicated purification process of graft copolymer.
In the existing graft copolymerization modification technology of PLA by NVP, there is no method for grafting PLA to prepare modified PLA materials by radiation method

Method used

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  • A method for preparing radiation graft copolymer of polylactic acid and N-vinyl pyrrolidone
  • A method for preparing radiation graft copolymer of polylactic acid and N-vinyl pyrrolidone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Distill the N-vinylpyrrolidone under reduced pressure to remove the polymerization inhibitor, the vacuum degree is -0.065MPa, seal the N-vinylpyrrolidone from which the polymerization inhibitor has been removed, and place it in a refrigerator for use. Store at 0°C.

[0028] Weigh 3 g of N-vinylpyrrolidone from which the polymerization inhibitor was removed, and dissolve it in 30 g of methanol to form a solution. Measure 18 ml of the methanol solution of N-vinylpyrrolidone, pour it into an ampule bottle, then weigh 0.5 g of polylactic acid, put it into the ampule bottle, and make it completely immersed in the methanol solution of N-vinylpyrrolidone. Vacuumize and fill with nitrogen repeatedly for 5 times, and finally seal the tube with nitrogen. The sealed tube sample is sent to the irradiation field to 60 Co-γ was irradiated at room temperature, the absorbed dose was 1.0kGy, and the dose rate was 5kGy / h.

[0029] The irradiated sample was taken out, immersed in disti...

Embodiment 2

[0032] Distill the N-vinylpyrrolidone under reduced pressure to remove the polymerization inhibitor, the vacuum degree is -0.098MPa, seal the N-vinylpyrrolidone from which the polymerization inhibitor has been removed, and place it in a refrigerator for use. Store at 0°C.

[0033] Weigh 10 g of N-vinylpyrrolidone from which the polymerization inhibitor was removed, and dissolve it in 23 g of methanol to form a solution. Measure 18 ml of N-vinylpyrrolidone solution and pour it into an ampoule. Put 0.5g of polylactic acid into the ampoule and completely soak it in the solution of N-vinylpyrrolidone. Vacuumize and fill with nitrogen repeatedly for 5 times, and finally seal the tube with nitrogen. The sealed tube sample is sent to the irradiation field to 60 Co-γ radiation originates from irradiation at room temperature, the absorbed dose is 5kGy, and the dose rate is 2.5kGy / h.

[0034] The irradiated sample was taken out, immersed in distilled water at 30°C for 4 hours, then ...

Embodiment 3

[0036] Distill the N-vinylpyrrolidone under reduced pressure to remove the polymerization inhibitor, the vacuum degree is -0.085MPa, seal the N-vinylpyrrolidone from which the polymerization inhibitor has been removed, and place it in a refrigerator for use. Store at 0°C.

[0037] Weigh 40 g of methanol, 10 g of ethanol and 0.5 g of hydrochloric acid with a concentration of 36% (mass percentage concentration) respectively, and mix them to form a composite solvent. Weigh 6 g of N-vinylpyrrolidone from which the polymerization inhibitor has been removed, and dissolve it in a composite solvent of methanol and ethanol. Measure 15 ml of N-vinylpyrrolidone solution and pour it into an ampoule. Put 0.3g of polylactic acid into the ampoule and completely soak it in the solution of N-vinylpyrrolidone. Vacuumize and fill with nitrogen repeatedly for 5 times, and finally seal the tube with nitrogen. The sealed tube sample is sent to the irradiation field to 60 The Co-γ radiation sour...

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Abstract

The invention discloses a method for preparing radiation graft copolymer of polylactic acid (PLA) and N-vinyl pyrrolidone (NVP) by applying[60]Co-gamma ray source to initiate graft reaction, comprising the following steps: A. dissolving the monomer NVP removed with polymerization inhibitor into methanol or compound organic solvent containing methanol; B soaking PLA into NVP solution, performing radiation grafting under the existence of nitrogen; C washing the PLA processed with radiation grafting by water or ethanol for removing unreacted monomer and homopolymer, and drying in vacuum to obtainthe polylactic acid and NVP graft copolymer (PLA-g-PVP). The invention can control the percent grafting of the copolymer by selecting different absorbed dosages, featured by simple process, convenient operation, non-catalyst in reaction system, safety and environmental protection.

Description

technical field [0001] The present invention relates to a kind of preparation method of graft copolymer, specifically, the present invention relates to a kind of adopting 60 The invention discloses a method for preparing polylactic acid and N-vinylpyrrolidone graft copolymer by Co-gamma ray irradiation. It belongs to the field of biomedical materials. Background technique [0002] Polylactic acid (PLA) is a type of polymer synthesized by chemical methods with lactic acid as a monomer. It is non-toxic, non-irritating and has good biocompatibility. It can be biodegraded and absorbed. It is used as a surgical implant. It can be removed without secondary surgery, and PLA also has the advantages of plasticity and processing, so it is widely used in the field of biomedical materials. In particular, poly-L-lactic acid (PLLA) has important application prospects in the field of human body scaffold materials due to its high strength and other advantages. However, PLLA has high cryst...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F283/02
Inventor 陈浩彭朝荣陈竹平王静霞
Owner SICHUAN INST OF ATOMIC ENERGY
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