Refining method of adenylic acid
A purification method, adenylic acid technology, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of low liquid chromatography content and low product yield, etc.
Active Publication Date: 2012-12-12
SHANDONG KAISHENG NEW MATERIALS
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Problems solved by technology
These salts will crystallize and precipitate together with the product adenylic acid during the recrystallization process, so it is difficult to completely remove them from the product with traditional recrystallization processes
The organic impurities in the crude adenylic acid are also difficult to separate completely by recrystallization, so the liquid chromatography content of the 5'-adenylic acid product obtained by the traditional recrystallization method is low, generally below 98%, and the product yield rate is also lower
Method used
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Embodiment 1
[0015] Weigh 20 g of crude adenylic acid, make it into a 1% aqueous solution, adjust the pH value to 12.5, and add it into a glass column containing 400 ml of activated carbon. After fully soaking for 1 hour, release it, collect it into a glass beaker, adjust the pH value of the collected refined liquid to 3.0, then add 150ml of alcohol, adenylic acid crystals are precipitated, and after conventional separation and drying, adenylic acid product, product The liquid chromatography content is 99.64%.
Embodiment 2～6
[0017]
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The invention discloses a method for obtaining high-content adenylic acid by utilizing active carbon to conduct refining on adenylic acid crude product. The method comprises the concrete steps: firstly the adenylic acid crude product is proportioned to be 1-3% aqueous solution with pH of 8-13 and then the aqueous solution is added to an active carbon column to conduct dipping treatment; the ratio of the weight (g) of the adenylic acid crude product to the volume (ml) of the active carbon is 1:1.0-30 and the dipping time is controlled to be within 1-48 hours; the adenylic acid solution subjected to the above treatments has pH value regulated to 1-5 and is treated with crystallizing, filtering and drying by using solventing-out agents such as organic solvent ethanol and the like, so as to obtain the adenylic acid product with liquid phase content of over 99.5 percent.
Description
1. Technical field [0001] The invention relates to a fine chemical product, in particular to a method for refining adenylic acid. 2. Technical Background [0002] In addition to some isomers, adenosine and other organic components, the crude adenylic acid also contains more salts such as phosphate and sodium chloride. These salts will crystallize and precipitate together with the product adenylic acid during the recrystallization process, so it is difficult to completely remove them from the product with traditional recrystallization processes. The organic impurities in the crude adenylic acid are also difficult to separate completely by recrystallization, so the liquid chromatography content of the 5'-adenylic acid product obtained by the traditional recrystallization method is low, generally below 98%, and the product yield rate is also lower. 3. Contents of the invention [0003] The technical problem solved by the invention is to obtain products with higher adenosine...
Claims
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IPC IPC(8): C07H19/20C07H1/06
Inventor 王荣海宋道淮郗新才毕义霞田恒强
Owner SHANDONG KAISHENG NEW MATERIALS