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Application of argatroban in blood corpuscle and biochemical conventional analysis

A technology of routine analysis, argatroban, applied in the application field of argatroban in the routine analysis of blood cells and biochemistry, can solve the problems of waste of specimens, increase the pain of patients and medical costs, and achieve the effect of strong activity

Inactive Publication Date: 2012-07-18
AFFILIATED HOSPITAL OF NANTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When a patient examines different items, a variety of anticoagulant tubes are required, and each type of specimen is not fully utilized, resulting in a great waste of specimens, and increasing patient pain and medical costs

Method used

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  • Application of argatroban in blood corpuscle and biochemical conventional analysis
  • Application of argatroban in blood corpuscle and biochemical conventional analysis
  • Application of argatroban in blood corpuscle and biochemical conventional analysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] A use of argatroban in routine analysis of blood cells and biochemistry.

[0013] In the application of argatroban in routine analysis of blood cells and biochemistry, the concentration of argatroban is about 0.70-0.75 mg / ml when performing routine analysis of blood cells and biochemistry.

[0014] Experimental material of the present invention is as follows:

[0015] 1. Materials

[0016] Argatroban (Argatroban) was purchased from Tianjin Pharmaceutical Research Institute Pharmaceutical Co., Ltd. Appearance is white crystalline powder, purity 99.2%, batch number: 070814, CAS registration number: 74863-84-6, valid for 3 years. A blank test tube (siliconized glass) without any additives was purchased from Jiangsu Kangjian Medical Supplies Co., Ltd., batch number: 080718, with a validity period of 2 years, a specification of 3ml, and a size of 13×75mm. According to the experimental design scheme, a certain amount of argatroban was weighed and added into a blank test tu...

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PUM

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Abstract

The invention discloses an application of argatroban in blood corpuscle and biochemical conventional analysis. The argatroban selected by the invention is a thrombin inhibitor with strong activity and high selectivity, and can be directly combined with thrombin (factor IIa), thus not only inactivating free thrombin in blood but also inactivating thrombin combined with fibrin; the argatroban can inhibit fibrin formation and platelet aggregation caused by thrombin, thus achieving the aim of anticoagulation. At present, the majority of clinical laboratories issue blood corpuscle and conventionalbiochemical analysis report in a working day (8h). The invention selects the argatroban with concentration being 0.7mg / ml by tests of repeatability, stability and interference, as the argatroban can ensure blood not to be coagulated in 10h.

Description

Technical field: [0001] The invention relates to a new application of a reagent. Background technique: [0002] Blood specimens are the most commonly used specimen type in clinical laboratories. Commonly used blood sample anticoagulants such as EDTA-K 2 , heparin lithium, etc. can interfere with the detection of certain items, so it is only limited to anticoagulation of certain types of specimens [1-3] . When patients check different items, they need to use multiple anticoagulation tubes, and each type of specimen is not fully utilized, resulting in a great waste of specimens, and increasing patient pain and medical costs. Therefore, seeking a universal anticoagulant is an urgent problem to be solved, but there are few research reports on the use of new anticoagulants in clinical laboratories at home and abroad. Argatroban (Argatroban) can strongly directly inhibit the activity of thrombin (IIa), prevent blood coagulation, and will not cause side effects such as bleeding...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/48G01N33/50
Inventor 崔明王惠民
Owner AFFILIATED HOSPITAL OF NANTONG UNIV