Carboxymethyl curdlan gum physical hydrogel and preparation method thereof

A technology of carboxymethyl cod gum and physical water, applied in the field of hydrogel and its preparation, carboxymethyl cod gum physical hydrogel and its preparation field, to achieve the simple and convenient preparation method, prolong the freezing time, and reduce the freezing time The effect of temperature

Inactive Publication Date: 2009-12-16
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After searching the prior art literature, it is found that there is no public report on the technology of preparing carboxymethyl kadum physical hydrogel by freezing and thawing.

Method used

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  • Carboxymethyl curdlan gum physical hydrogel and preparation method thereof
  • Carboxymethyl curdlan gum physical hydrogel and preparation method thereof
  • Carboxymethyl curdlan gum physical hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Accurately weigh 0.10 g of carboxymethyl cod gum and dissolve it in double-distilled water to prepare a 1% carboxymethyl cod gum aqueous solution.

[0022] (2) Use 1 mol / L HCl to adjust the pH value of the carboxymethyl cod gum aqueous solution prepared in step (1) to make it pH=1.50, and let it stand for later use.

[0023] (3) Seal the solution prepared in step (2), place it in a low-temperature thermostat, and freeze it at -24°C for 48 hours, then take it out and thaw it at room temperature for 2 hours, and perform a freeze-thaw cycle on the resulting gel. Dialysis in deionized water to remove components such as acid and sodium chloride can make spongy carboxymethyl cod gum physical gel, the hydrogel component content is 6.7%, the molecular formula of carboxymethyl cod gum for:

[0024]

[0025] Where: R is CH 2 COOH or H, CH 2 The degree of substitution of COOH is 0.83, and the value of n is 3000.

Embodiment 2

[0027] (1) Accurately weigh 0.10 g of carboxymethyl cod gum and dissolve it in double-distilled water to prepare a 1% carboxymethyl cod gum aqueous solution.

[0028] (2) Use 1 mol / L HCl to adjust the pH value of the carboxymethyl cod gum aqueous solution prepared in step (1) to make it pH=1.50, and let it stand for later use.

[0029] (3) Seal the solution prepared in step (2), place it in a low-temperature thermostat, and freeze it at -24°C for 48 hours, then take it out and thaw it at room temperature for 2 hours, and then perform the above-mentioned freeze-thaw cycle twice, The resulting gel was dialyzed in deionized water to remove components such as acid and sodium chloride to obtain a spongy carboxymethyl

[0030] De gum physical gel, the hydrogel component content is 7.4%, the molecular formula of carboxymethyl cod gum is:

[0031]

[0032] Where: R is CH 2 COOH or H, CH 2 The degree of substitution of COOH is 0.83, and the value of n is 3000.

Embodiment 3

[0034] (1) Accurately weigh 0.10 g of carboxymethyl cod gum and dissolve it in double-distilled water to prepare a 1% carboxymethyl cod gum aqueous solution.

[0035] (2) Use 1 mol / L HCl to adjust the pH value of the carboxymethyl cod gum aqueous solution prepared in step (1) to make it pH=1.50, and let it stand for later use.

[0036] (3) Seal the solution prepared in step (2), place it in a low-temperature thermostat, freeze it at -24°C for 48 hours, then take it out and thaw it at room temperature for 2 hours, and then perform the above-mentioned freeze-thaw cycle four times, The resulting gel was dialyzed in deionized water to remove components such as acid and sodium chloride to obtain a spongy, stronger carboxymethyl cod gum physical gel. The hydrogel component content was 7.9%. The molecular formula of carboxymethyl cod gum is:

[0037]

[0038] Where: R is CH 2 COOH or H, CH 2 The degree of substitution of COOH is 0.83, and the value of n is 3000.

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Abstract

The invention provides a carboxymethyl curdlan gum physical hydrogel and a preparation method thereof, belonging to the technical field of high polymer material; the mass percent of the carboxymethyl curdlan gum physical hydrogel is 3-20% while the balance is water. The preparation method comprises the following steps: preparing carboxymethyl curdlan gum aqueous solution; regulating pH value and performing freeze-thaw treatment; compared with the prior art, the invention adopts the freeze-thaw treatment to prepare carboxymethyl curdlan gum physical hydrogel; the preparation method is easy and convenient and the strength of the hydrogel can be enhanced through increasing freeze-thaw circling times, reducing freeze temperature, prolonging freeze time and the like; no chemical cross-linking agent or organic solvent with poison and side effect to organism is introduced in the hydrogel preparation process with freeze-thaw treatment. The carboxymethyl curdlan gum has immunity activity and anti-tumor activity, so the physical hydrogel has potential application in biomedical sciences, such as being taken as sustained and control drug carrier, and has more advantages compared with other hydrophilic gums.

Description

technical field [0001] The invention relates to a hydrogel in the technical field of polymer materials and a preparation method thereof, in particular to a carboxymethyl cod gum physical hydrogel and a preparation method thereof. Background technique [0002] Among the many polymer materials that can be used to form hydrophilic colloids, polysaccharides are the most ideal choice due to their excellent properties such as hydrophilicity, biocompatibility, and biodegradability. Curdlan polysaccharide (curdlan) is a straight-chain pure 1,3-β-D-glucan fermented by microorganisms. In addition to the above properties, it also has unique gel properties. Its aqueous suspension depends on the heating temperature. High and low, thermoreversible and thermoirreversible gels can be formed [KNishinari, H Zhang&T.Funami.Curdlan.In Handbook ofHydrocolloids(2 nd Ed.), Chapter 20, 567-591, G.O Phillips & P.A. Williams, Eds., Woodhead Publishing Ltd.: England, 2009]. However, Kede gum is inso...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00C08J3/075C08L5/00
Inventor 邬娟张洪斌
Owner SHANGHAI JIAO TONG UNIV
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