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Application of Huaiqihuang particle compound preparation in kidney disease treatment

A compound preparation and granule technology, which is applied in the application field of Huaiqihuang granule compound preparation in the treatment of kidney disease, can solve the problems of long treatment cycle, affecting disease treatment, kidney toxicity and side effects, and achieves small adverse reactions, good treatment of kidney disease, good therapeutic effect

Active Publication Date: 2010-01-13
QIDONG GAITIANLI MEDICINES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Kidney disease is a serious threat to human life and health. Tens of millions of patients die of kidney disease every year. Primary nephrotic syndrome is a common urinary system disease in pediatrics. The main clinical manifestations are proteinuria, hypoproteinemia, hyperlipidemia Hyperemia and different degrees of edema, the annual death of children due to primary nephrotic syndrome is on the rise. At present, the main treatment of primary nephrotic syndrome is adrenal glucocorticoid-based drugs, and the treatment cycle is long. Long-term use of this drug Drugs like these can cause a decrease in the immune function of the body, thereby affecting the treatment of the disease, and long-term use of glucocorticoid drugs will bring many adverse reactions
Clinical and animal experiments have shown that the pathogenesis of primary nephrotic syndrome is related to immune dysfunction. At the same time, glomerulonephritis is also a major disease that endangers human life and health. The number of deaths due to glomerulonephritis is increasing year by year. High, the current treatment of glomerulonephritis is mainly based on chemical drugs, but long-term use of chemical drugs will produce a variety of adverse reactions, and some drugs will cause serious toxic side effects to the kidneys through renal excretion

Method used

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  • Application of Huaiqihuang particle compound preparation in kidney disease treatment
  • Application of Huaiqihuang particle compound preparation in kidney disease treatment
  • Application of Huaiqihuang particle compound preparation in kidney disease treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Pharmacological effects of Huaiqihuang granule compound preparation on primary nephrotic syndrome.

[0018] 1. Experimental materials

[0019] Thirty male clean-grade SD rats, weighing 160-180 g, were purchased from Shanghai Slack Animal Center. Adriamycin (California, USA) and dexamethasone injection were provided by Nanjing Children’s Hospital, Huaiqihuang granule compound preparation was provided by Jiangsu Qidong Gaitianli Pharmaceutical Co., Ltd., and ED-1 monoclonal antibody was purchased from British Serotec Company, FITC-labeled goat anti-mouse IgG was purchased from Beijing Zhongshan Biotechnology Company. TNF-α and IL-1β ELISA kits were purchased from Jingmei Bioengineering Co., Ltd. and Invitrogen Corporation of the United States, respectively.

[0020] 2. Construction and experimental grouping of Adriamycin nephropathy model

[0021] SD rats were adaptively fed for 1 week, and randomly divided into 5 groups of 6 rats in each group: ①Adriamycin ...

Embodiment 2

[0048] Example 2 The pharmacological effect of Huaiqihuang granule compound preparation on glomerulonephritis.

[0049] 1. Experimental materials

[0050] 24 healthy male SD rats, 4 weeks old, weighing about 160g, were purchased from the Experimental Animal Center of Jiangsu Province; the compound preparation of Huaiqihuang Granules was provided by Jiangsu Qidong Gaitianli Pharmaceutical Co., Ltd.; complete Freund's adjuvant, FITC labeling The goat anti-rabbit IgG and Schiff reagent were purchased from Sigma, USA, and transforming growth factor (TGF-β 1 ) polyclonal antibody was purchased from Sant Cruz Company in the United States, proliferating cell nuclear antigen (PCNA) monoclonal antibody and monocyte chemoattractant-1 (MCP-1) monoclonal antibody were purchased from Wuhan Boster Bioengineering Co., Ltd. Oxidase-labeled goat anti-rabbit IgG, normal goat serum blocking solution, and DAB chromogen were purchased from Beijing Zhongshan Biotechnology Company.

[0051] 2. Exp...

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Abstract

The invention discloses application of a Huaiqihuang particle compound preparation in kidney disease treatment. Proved by pharmacological test researches, the Huaiqihuang particle compound preparation has excellent effect of kidney protection, similar therapeutical effect as glucocorticoids on idiopathic nephrotic syndromes induced by amycin and good therapeutical effect on glomerulonephritis. The traditional Chinese medicine compound preparation has easy obtaining of raw materials, strong pharmacological activity and low adverse reaction and is hopeful to become a medicament for treating kidney diseases of a new generation.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine, in particular to a compound preparation of Huaiqihuang granules, and in particular to the application of the compound preparation of Huaiqihuang granules in treating nephropathy. Background technique [0002] Kidney disease is a serious threat to human life and health. Tens of millions of patients die of kidney disease every year. Primary nephrotic syndrome is a common urinary system disease in pediatrics. The main clinical manifestations are proteinuria, hypoproteinemia, hyperlipidemia Hyperemia and different degrees of edema, the annual death of children due to primary nephrotic syndrome is on the rise. At present, the main treatment of primary nephrotic syndrome is adrenal glucocorticoid-based drugs, and the treatment cycle is long. Long-term use of this drug Drugs like these can cause a decrease in the immune function of the body, thereby affecting the treatment of the disease, and l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/14A61P13/12
Inventor 黄松明张爱华朱春华陆正鑫
Owner QIDONG GAITIANLI MEDICINES
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