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Application of compound polygonum orientale preparation in preventing and treating climacteric diseases and delaying senility

A technology of compound oriental grass and preparation, applied in sexual diseases, bone diseases, nervous system diseases, etc., can solve problems such as the prevention and treatment of menopausal diseases that have not been seen

Inactive Publication Date: 2010-01-27
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the clinical pharmacological research on the prevention and treatment of menopausal diseases and aging by using the compound sage grass preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] Embodiment 1: the preparation of injection

[0136] Raw materials: 7500g of sage, 1500g of escutellaria

[0137] Preparation method: take Chinese sage and add 10 times of water to decoct 3 times, each time for 1 hour, filter, combine the filtrate, concentrate under reduced pressure, add ethanol to make the alcohol content reach 65%, let it stand for 12 hours, suction filter, and take the supernatant liquid, the filtrate was extracted 3 times with ethyl acetate, the ethyl acetate solution was discarded, the aqueous layer was combined, the pH value was adjusted to 3 with hydrochloric acid, the n-butanol saturated with water was extracted 4 times, the n-butanol solution was combined, washed with water, and the Recover n-butanol under pressure, dissolve the residue with 80% ethanol, put it on a polyamide column (500g, Φ8cm, diameter-to-height ratio 1:6, adsorption flow rate 1.5BV / h), collect the flow-through and eluent, and recover ethanol. The residue was vacuum-dried to ...

Embodiment 2

[0141] Embodiment 2: the preparation of tablet

[0142] Raw material: 1000g of Chinese sage, 5000g of escutellaria

[0143]Preparation method: take the sage, add 4 times the amount of water to decoct once, decoct for 0.5 hours, filter, combine the filtrate, concentrate under reduced pressure to a relative density of 1.05 (50°C), add ethanol to make the alcohol content reach 20%, Stir evenly, let stand for 6 hours, filter with suction, recover ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.04 (50°C), adjust the pH value to 4.7 with saturated sodium carbonate, stir well, let stand for 1 hour, take the supernatant and filter After that, the filtrate was extracted once with 1 / 4 times the amount of ethyl acetate, discarded the ethyl acetate solution, combined the aqueous layer, adjusted the pH value to 1 with hydrochloric acid, and extracted with 1 / 4 times the amount of water-saturated n-butanol Twice, combine the n-butanol solution, wa...

Embodiment 3

[0147] Embodiment 3: the preparation of capsule

[0148] Take 100g of Orangus chinensis and 1000g of Erigeron breviscapus, pulverize, mix evenly, decoct with water, filter, concentrate the filtrate under reduced pressure to form an extract, add conventional excipients for capsules, and prepare capsules according to conventional preparation processes.

[0149] Dosage: Oral: 75mg crude drug / kg body weight / day. It has definite curative effect on kidney disease.

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Abstract

The invention relates to application of a Chinese medicinal preparation, in particular to application of a compound polygonum orientale preparation in preparing medicaments for preventing and treating climacteric diseases and delaying senility, wherein the compound polygonum orientale preparation consists of polygonum orientale and erigeron breviscapus.

Description

technical field [0001] The invention relates to an application of a traditional Chinese medicine preparation, in particular to an application of a compound radishes root preparation in the preparation of medicines for preventing and treating menopausal diseases and delaying aging. technical background [0002] In medicine, the age stage of 45-55 years old for women and 50-60 years old for men is generally called menopause. Menopause is an important stage in life. At this stage, there are great changes in people's physiology. The immune function against diseases is reduced, the function of the neuroendocrine system is gradually declining, and the level of hormones is reduced. It often brings a series of physical diseases and emotional disorders. At the same time, they are under pressure from work, study, family, marriage and all aspects of society, so there are also obvious psychological changes. [0003] Women transition from childbearing age to old age, due to a series of ...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K9/08A61K9/19A61K9/48A61K9/20A61P15/12A61P25/24A61P19/10A61P39/06
Inventor 窦啟玲周黎亚
Owner GUIZHOU YIBAI PHARMA CO LTD
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