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Preparation method of concentrated pills

A technology for concentrating pills and materials, which can be used in medical preparations of inactive ingredients, pill delivery, pharmaceutical formulations, etc., and can solve problems such as slow disintegration

Inactive Publication Date: 2011-06-22
LUOYANG JUSN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Concentrated pills are generally composed of extracts and powders of traditional Chinese medicines, or directly from extracts of traditional Chinese medicines. After drying, they are dense and hard. During the process of disintegration, water cannot quickly enter its interior. Slow to dissolve and therefore slow to disintegrate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The disintegrant uses the following ingredients and proportions:

[0019] Talc 10%

[0020] Sodium Carboxymethyl Cellulose 20%

[0021] Sodium Sulfate 70%

[0022] The above are all powdered ingredients, after directly mixing in proportion, add and mix evenly by 5% of the weight of the combined material when the concentrated pellets are combined; take 95% edible ethanol as the binder to make pills, and the edible ethanol of 95% is 30% of the combined weight of the material. Results The finished pellets were formed well, and the disintegration time limit was 26 minutes, which met the regulations.

Embodiment 2

[0024] The disintegrant uses the following ingredients and proportions:

[0025] Talc 15%

[0026] Sodium Carboxymethyl Cellulose 25%

[0027] Sodium Sulfate 60%

[0028] The above are all powdered ingredients, after directly mixing in proportion, add and mix evenly by 5% of the weight of the combined material when the concentrated pellets are combined; take 95% edible ethanol as the binder to make pills, and the edible ethanol of 95% is 30% of the combined weight of the material. Results The finished pellets were formed well, and the disintegration time limit was 29 minutes, which met the regulations.

Embodiment 3

[0030] The disintegrant uses the following ingredients and proportions:

[0031] Talc 20%

[0032] Sodium Carboxymethyl Cellulose 30%

[0033] Sodium Sulfate 50%

[0034] The above are all powdered ingredients, after directly mixing in proportion, add and mix evenly by 5% of the weight of the combined material when the concentrated pellets are combined; take 95% edible ethanol as the binder to make pills, and the edible ethanol of 95% is 30% of the combined weight of the material. Results The finished pellets were formed well, and the disintegration time limit was 25 minutes, which met the regulations.

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PUM

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Abstract

The invention relates to the preparation technology of medicine, and mainly provides a preparation method of concentrated pills. A disintegrant comprises the components by mass percent: 10-20% of talcum powder, 20-30% of sodium carboxymethyl cellulose and 50-70% of sodium sulfate which are in a state of powder; after the components are directly mixed together according to the proportion; when being lumped, the concentrated pills are added to be evenly mixed based on 5% of the weight of the lumped materials; 95% of edible ethanol is taken as binding agent for preparing the bills, and the weight of the 95% of edible ethanol is 30% of that of the lumped materials. The pills prepared by the method can be disintegrated within 30min, so asto be far shorter than 2h specified by pharmacopeia.

Description

technical field [0001] The invention relates to the preparation technology of medicines, and mainly proposes a preparation method of concentrated pills. Background technique [0002] Concentrated pills are generally composed of traditional Chinese medicine extracts and medicinal powders, or directly composed of traditional Chinese medicine extracts. After drying, the texture is dense and hard. During the disintegration process, water cannot quickly enter its interior. Slow to dissolve and therefore slow to disintegrate. Contents of the invention [0003] The purpose of this invention is to propose a kind of preparation method of concentrated pill. [0004] In the preparation method of the concentrated pill proposed by the present invention, the composition and mass percentage of the disintegrant are: [0005] Talc 10-20% [0006] Sodium Carboxymethyl Cellulose 20-30% [0007] Sodium sulfate 50-70%; [0008] The above are all powdered ingredients, after directly mixing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/02A61K9/20
Inventor 王旭照邓占元王朝阳
Owner LUOYANG JUSN PHARMA
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