Method for establishing artery ischemia model of brain of rhesus monkey and evaluation method

Abstract

The invention relates to a method for establishing an artery ischemia model of a brain of a rhesus monkey and an evaluation method. The constructing method adopts the mode of directly puncturing femoral arteries of an experimental monkey to perform the intravascular interventional operation under the direct view of a digital subtraction angiography, and establishes the chronic cerebral infarctionprimate model by using a micro-catheter to block the arteries in the brain of the experimental monkey and controlling ischemia time. The model is a quite reasonable cerebral ischemia-reperfusion animal model, and the pathological characteristics of the monkey cerebral injury model established by the method are similar to clinical manifestation; and moreover, the model is stable and reliable and issuitable for all kinds of curing therapeutic research and related basic research.

Description

technical field [0001] The invention relates to a method for constructing and evaluating a rhesus monkey middle cerebral artery ischemia model, which belongs to the field of medicine. Background technique [0002] Animal models of cerebral infarction play a very important role in various studies of ischemic cerebrovascular diseases, especially in the evaluation of various treatment methods, such as the evaluation of new drugs. Animals currently used in this research include rats, rabbits, dogs, cats, and primates such as rhesus monkeys and baboons. Rats, rabbits and other small animals are widely used due to the advantages of economy and simple operation. However, the species differences between these animals and humans are large, which leads to the discrepancy between the results obtained in animal experiments and clinical experiments. Monkeys are very close to humans in species, and their sensorimotor functions are similar to humans. The shape of monkey brain tissue, th...

AI Technical Summary

Problems solved by technology

This type of model has a large surgical trauma, and the embolization depends entirely on the experience of the operator rather than direct vision under contrast imaging. It is impossible to accurately block a certain part of the middle cerebral artery, and it is likely to cause a large difference in the ischemic effect of the model, which is not conducive to further research.

[0006] However, these methods have their own deficiencies in the operability, consistency and authenticity of simulating the pathophysiological process of human cerebral ischemia

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