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Preparation method of fucoidan sulfuric ester with high purity and high-sulfate radical content
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A sulfate fucoidan sulfate and fucoidan sulfate technology are applied in the field of preparation of high-purity high-sulfate fucoidan sulfate, can solve problems such as low sulfate content, and achieve the use of organic solvents Few, simple method, few steps effect
Inactive Publication Date: 2011-05-11
SHANDONG UNIV AT WEIHAI
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[0005] For above-mentioned prior art, in order to solve the problem that sulfate radical content is low in the fucoidan sulfate product, the present invention provides a kind of preparation method of high-purity high sulfate radical fucoidan sulfate
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Embodiment 1
[0017] Embodiment 1 prepares a kind of high-purity high sulfate radical fucoidan sulfate ester:
[0018] Take 1 kg of dry kelp, add 8 kg of water to the dry kelp and soak for 0.5 hours, rinse the kelp gently, remove the sediment, and then mince the kelp to a size of 0.2 to 1 cm. Add 16 kg of 95% ethanol to the sea-tangle and stir for extraction, extract at 50°C for 0.5 hours, and separate the sea-tangle, then add 40kg of water, stir and extract at 50°C for 3 hours, extract twice, and separate the sea-tangle residue and supernatant. Add excess calcium chloride to the supernatant, let it stand for 2 hours, and filter the extract with a 200-300 mesh filter cloth. The filtrate was filtered with a hollow fiber membrane with a pore size of 2 microns. The filtrate is then concentrated to 8kg through a hollow fiber membrane of MW60000~100000, then add 24kg of water, then concentrate to 8kg, then add 24kg of water, and then concentrate to 8kg to remove most of the small molecular subs...
Embodiment 2
[0019] Embodiment 2 prepares a kind of high-purity high sulfate group fucoidan sulfate:
[0020] Take 3 kg of dry kelp, add 25 kg of water to the dry kelp and soak for 0.5 hour, rinse the kelp gently, remove the sediment, and then grind the kelp to a size of 0.2 to 1 cm. Add 50kg of 95% ethanol to the kelp and stir for extraction, extract at 50°C for 1 hour, and separate the kelp, then add 120kg of water, extract with stirring at 50°C for 3 hours, extract twice, and separate the kelp residue and supernatant. Add excess calcium chloride to the supernatant, let it stand for 2 hours, and filter the extract with a 200-300 mesh filter cloth. The filtrate was filtered with a hollow fiber membrane with a pore size of 2 microns. The filtrate is then concentrated to 20kg through a hollow fiber membrane of MW60000-100000, then added 60kg of water, then concentrated to 20kg, then added 60kg of water, and then concentrated to 20kg to remove most of the small molecular substances. Finall...
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Abstract
The invention discloses a preparation method of fucoidan sulfuric esterwith high purity and high-sulfate radical content, comprising the following steps: (1) adding water in dry kelp for soaking and rinsing to remove sediment and then grinding; (2) adding the kelp in 95 percent ethanol for stirring, extracting and separating to obtain kelp residue A; (3) adding water in the kelp residue A, adjusting the pH value to 6-8, and stirring, extracting and separating the mixture to obtain kelp residue B and supernatant; (4) adding super calcium chloride in the supernatant, standing and filtering to obtain filtrate; (5) condensing the filtrate to concentrated solution; and (6) directly spraying and drying the condensed solution, or depositing the fucoidan with 40-70 percent ethanol and drying and crushing the dried fucoidan, and finally obtaining the fucoidan sulfuric ester with high purity and high-sulfate radical content, wherein the content of fucose is 40-70 percent and the content of sulfate radical is 30-50 percent. Compared with the prior art, the invention is free from using acid base for treatment and adjusting the pH value, has simple method, less consumption of organic solvent, few steps and low cost, and is suitable for industrial production.
Description
technical field [0001] The invention relates to a preparation method of high-purity and high-sulfate radical fucoidan sulfate Background technique [0002] Fucoidan sulfate, English name Fucoidan, also known as fucoidan, fucoidan sulfate, fucoidan, fucoidan, etc., is mainly composed of sulfate-containing fucose (Fucose), followed by A small amount of galactose, mannose, xylose, arabinose, uronic acid, etc., is a water-soluble heteropolysaccharide, and its main active ingredient is α-L-fucose-4-sulfate. [0003] Fucoidan sulfate is an excellent health food and pharmaceutical raw material. Because it naturally contains sulfate, it has the characteristics of anionic polymer compounds. Studies have shown that fucoidan sulfate has various physiological activities such as anticoagulant, hypolipidemic, anti-chronic renal failure, anti-tumor, anti-virus, promotion of tissue regeneration, inhibition of gastric ulcer, and enhancement of the body's immune function. Fucoidan sulfate i...
Claims
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