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Methods for treating cancer using agents that inhibit wnt16 signaling

A signal transduction, -wnt16 technology, applied in the field of inhibiting the growth of cancer cells overexpressing Wnt 16 protein, can solve problems such as inability to provide compounds

Inactive Publication Date: 2010-03-31
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Thus, prior art cannot provide clear evidence that compounds that modulate the Wnt 16 pathway can be used to treat cells overexpressing Wnt 16, especially cancer cells

Method used

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  • Methods for treating cancer using agents that inhibit wnt16 signaling
  • Methods for treating cancer using agents that inhibit wnt16 signaling
  • Methods for treating cancer using agents that inhibit wnt16 signaling

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Abstract

This invention relates to methods of inhibiting the growth of cells, in particular cancer cells that over express Wnt16 protein. The methods comprise contacting the cell with an agent that binds to Wnt16 mRNA or Wnt16 protein, interferes with Wnt16 signaling or inhibits binding of the Wnt16 protein to another protein, such as a Frizzled receptor.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to provisional application 60 / 586,564, filed July 9, 2004, and provisional application 60 / 645,709, filed January 20, 2005, each of which is incorporated herein by reference in its entirety. technical field [0003] The present invention relates to a method for inhibiting the growth of cancer cells overexpressing Wnt 16 protein. The methods include contacting the cell with an agent that binds to Wnt 16 mRNA or Wnt 16 protein, interferes with Wnt 16 signaling, or inhibits binding of Wnt 16 protein to other proteins such as Frizzled receptors. Background technique [0004] Lung cancer is the leading cause of cancer death in the United States and the world, with about >170,000 newly diagnosed cases in the United States each year, and almost 1 million cases worldwide (Minna et al., Cancer Cell.1 (1): 49- 52 (2002)). Although lung cancer treatment has made strong progress over the past f...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00A61K31/70C07K16/00C12N5/00C07H21/02C07H21/04C12Q1/68
CPCA61K48/00C07K2317/21C07K16/3023C07K2316/95C07K2317/55C07K2316/96C07K16/22A61K31/00C12N15/1135C12N2310/14A61K2039/505C07K16/3015C07K2317/73C07K16/3061C07K2317/75A61P35/00A61P35/02A61P43/00
Inventor 尤亮何飚徐志东D·M·雅布隆斯
Owner RGT UNIV OF CALIFORNIA