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Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof

A technology of antioxidant activity and extraction method, which is applied in the field of extraction of new compounds, can solve the problems of no report on the basis of active substances, no report on system research, etc., and achieve the effect of simple extraction and separation process and scavenging free radicals

Active Publication Date: 2010-05-12
TIANJIN TIANSHI BIOLOGICAL DEV
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Problems solved by technology

[0004] Cotton ginseng has long been recorded in the famous Tibetan medicine "Jingzhu Materia Medica". At present, only Chengdu Institute of Biology, Chinese Academy of Sciences has divided 28-epi-cyasterone, Eriophytonoide, Cyasterone, ajuforrestinsA and B, 20- hydroxyecdysone, polypodinB, ajugalactone, 8-O-acetylharpagid, apigenin, -sitosterol daucosterol, and N-[2-hydroxy-(nonadecanoyl-tricosanoyl)]-4-hydroxytrans-8-sphingenine and other compounds, while its fat-soluble part and water-soluble The systematic study of the sex part has not been reported yet, and at the same time, the research on the basis of its active substances has not been reported at home and abroad.

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  • Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof
  • Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof
  • Compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and extracting method thereof

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Embodiment Construction

[0017] The following accompanying drawings and preferred embodiments describe in detail the specific embodiments and features provided according to the present invention as follows:

[0018] The chemical structural formula of the compound with antioxidant activity obtained by the present invention is:

[0019]

[0020] The compound is colorless crystal, determined by ESI-MS m / z: 403 [M+Na] + , 425[M+HCOO - ] - , its molecular weight is 380, combined with 1 H-NMR (CD 3 OD) and 13 C-NMR (CD 3 OD) data, confirm that its molecular formula is C 16 H 28 O 10 , the degree of unsaturation is 3;

[0021] 1 H-NMR spectrum δ 4.69 (1H, d, J=7.8 Hz) and 13 C-NMR spectrum δ99.6 is the characteristic signal of terminal proton and terminal carbon of sugar, 13 C-NMR spectrum δ63.3 is sugar 6-CH 2 signal, combined 1 H-NMR spectrum δ3.87 (1H, dd, J=11.5, 1.7Hz) and δ3.64 (1H, dd, J=11.5, 5.5Hz), indicating a β-glucose group; 13 The C-NMR spectrum shows 16 signals, except for th...

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Abstract

The invention relates to a compound extracted from Tibetan medicine eriophyton wallichii with antioxidant activity and an extracting method thereof. The compound is identified as new iridoid through modern spectral analysis, wherein the molecular weight is 380, and the molecular formula is C16H28O10. The extracting method comprises the following steps of: pulverizing whole eriophyton wallichii; extracting with ethanol; sequentially extracting by using petroleum ether, ethylacetate and water saturated n-butanol; carrying out chromatography on the n-butanol part by macroporous absorption resin; and carrying out column chromatography on 10 percent of an elution part sequentially through silica gel, ODS-A and Sephadex LH-20 so as to obtain wallchiiside A. The new iridoid has simple preparation method, low cost and obvious activity and provides a new compound for developing medicaments having antioxidant effects.

Description

technical field [0001] The present invention relates to a method for extracting new compounds from Tibetan medicinal cotton ginseng, in particular to a compound with antioxidant activity extracted from Tibetan medicinal cotton ginseng and an extraction method thereof. Background technique [0002] Tibetan medicine is a unique medical and health care method formed by the Tibetan people in the long-term struggle with the natural environment, and it is a treasure of traditional medicine in the motherland. Tibet is a plateau environment with high cold, hypoxia, strong radiation and no pollution. Therefore, Tibetan medicine has the characteristics of long growth cycle, unique curative effect and high accumulation of active substances. Although there are Tibetan medicine health products on the market, the varieties are relatively simple, and the efficacy factors and their structure-activity-dose-effect relationships are not clear, which is not conducive to the development of the t...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08A61K31/7048A61P39/06A23L1/29A23L33/00
Inventor 范秋领赵明明
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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