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Rabbit triple inactivated vaccine, preparation method and application thereof

An inactivated vaccine and inactivated technology are applied in the field of rabbit triple inactivated vaccine and its preparation to achieve good immune efficacy and safety, reduce the number of vaccine injections, and have good immune safety effects.

Inactive Publication Date: 2010-05-19
哈药集团生物疫苗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still no triple inactivated vaccine product for rabbit viral hemorrhagic disease, Pasteurella multocida, and Clostridium perfringens (type A) in China

Method used

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  • Rabbit triple inactivated vaccine, preparation method and application thereof
  • Rabbit triple inactivated vaccine, preparation method and application thereof
  • Rabbit triple inactivated vaccine, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The preparation of embodiment 1 rabbit triple inactivated vaccine of the present invention

[0066] 1. Preparation of Rabbit Viral Hemorrhagic Disease Virus AV33 Strain Virus Liquid

[0067] 1.1 Preparation of poisonous seeds for production

[0068] Dilute the virus seeds 10 times with pH 7.2 phosphate buffer solution or normal saline, inoculate healthy rabbits with a susceptible body weight over 1.5kg, and inject 1ml subcutaneously into each rabbit. 24-72 hours after aseptic collection and inoculation, the liver and spleen of rabbits that are dying or have just died, and have typical pathological changes, shall be preserved as production-use virus species after passing the inspection. The subculture of poisonous seeds does not exceed 3 generations.

[0069] 1.2 Preparation of virus liquid for seedling production

[0070] Take the virus seed for production, dilute it 10 times with sterile normal saline, and inject 2ml subcutaneously into each rabbit. Within 24-96 ho...

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Abstract

The invention discloses a rabbit triple inactivated vaccine, a preparation method and the application thereof; the rabbit triple inactivated vaccine is formed mainly by rabbit hemorrhagic disease virus liquid which is inactivated and detoxified, rabbit pasteurella multocida liquid and rapid A type clostridium perfringens liquid which have 1:1:2 volume ratio; in the invention, by optimizing culture technology, concentration technology and immunizing dose and other measures, the rabbit triple inactivated vaccine which has good immunity effect and safety is obtained and can effectively control the rabbit hemorrhagic disease, the pasteurella multocida disease and the pasteurella multocida disease (A type) and reduce vaccine injection times of farmers, so as to reduce the stress reaction of animals and improve the production performance. The clinical application proves that the immunization effect of the rabbit triple inactivated vaccine is ideal, each rabbit is vaccinated with 2ml and has immunity after 5-7 days, the immune period is at least 180 days, and the immune safety is good without toxic and side effect.

Description

technical field [0001] The present invention relates to an inactivated vaccine for animals, in particular to a rabbit triple inactivated vaccine and a preparation method thereof. / and application in Clostridium perfringens (type A), belonging to the field of animal inactivated vaccines. Background technique [0002] Rabbit viral hemorrhagic disease is an acute and fatal infectious disease caused by calicivirus. The disease has an acute onset, short course of disease, rapid spread, and wide prevalence. Rabbits over 2 months old are susceptible, and there is no obvious seasonality. Its morbidity and mortality can be as high as 100%. Once the disease breaks out, it will cause huge economic losses to the rabbit industry. Pasteurellosis multocida in rabbits is a polymorphic disease, mainly type A rabbit pasteurellosis multocida, and the morbidity and mortality of acute cases are high, although the mortality rate of chronic cases is not high, However, the economic loss is huge...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61K39/12A61K39/102A61K39/02A61P31/04A61P31/14C12N7/00C12N1/20C12R1/01C12R1/145C12R1/93
Inventor 姜力吴金丁国杰白同臣马世华曲河甘一迪藏玉婷杨万秋胡瑛瑛崔艳丽
Owner 哈药集团生物疫苗有限公司
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