Prostate cancer survival and recurrence

Abstract

The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to prostate cancer. In particular, the disclosure is based on the identities of genes that are correlated with patient survival and prostate cancer recurrence. The gene expression profiles may be embodied in nucleic acid expression, protein expression, or other expression formats and used to predict the survival of subjects afflicted with prostate cancer and to predict prostate cancer recurrence. The profiles may also be used in the study and/or diagnosis of prostate cancer cells and tissue as well as for the study and/or determination of prognosis of a patient. When used for diagnosis or prognosis, the profiles may be used to determine the treatment of prostate cancer based upon probable life expectancy and cancer recurrence and/or metastasis.

Description

related application This application claims priority to U.S. Provisional Patent Application 60 / 891,477, filed February 23, 2007 (with a 12-month deadline on Saturday, February 23, 2008), which is incorporated herein by reference as if The full text is listed as such. technical field The present invention contemplates the identification and use of profiles or patterns of expression of genes (or sequences) that are clinically relevant to prostate cancer. In particular, the invention is based on the identification of genes or expressed sequences whose expression correlates with patient survival, recurrence of prostate cancer and / or appearance of metastasis of prostate cancer. Gene expression profiles, expressed as nucleic acid expression, protein expression, or other forms of expression, can be used to predict survival of a subject with prostate cancer, predict prostate cancer recurrence, and / or predict the occurrence of prostate cancer metastasis. The profile can also be use...

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Problems solved by technology

However, some patients fail treatment

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