Micro-capsule containing vitamin D3

Abstract

The invention relates to a micro-capsule containing vitamin D3 and a preparation method thereof. The recipe of the micro-capsule contains a liquid paraffin solution of the vitamin D3, acacia and gelatin. The used method comprises the following steps: firstly, preparing the original emulsion of the vitamin D3 by a compound coagulation method, then solidifying by formaldehyde to obtain the suspension of the micro-capsule and finally, processing by microcrystalline cellulose to obtain the dry micro-capsule granules of the vitamin D3. The micro-capsule has accurate fractional dose, favorable stability, simple production process and convenient use and is easily accepted by a patient.

Description

technical field [0001] The invention relates to a microcapsule, in particular to a microcapsule containing vitamin D3 and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Vitamin D3 has strong pharmacological activity, and a small amount of drugs can produce strong physiological effects. It needs a preparation that can be evenly distributed, otherwise the local concentration will be too high, and toxic and side effects will easily occur. The Chinese Pharmacopoeia has collected soft capsules of vitamin D3. Although it can disperse the drug evenly, it also has inherent defects, such as long production cycle, complicated process, and poor stability of the preparation. For some special groups, it is inconvenient to swallow. Although the capsule can be cut into small openings and the internal medicinal liquid can be squeezed out to take, the soft capsule has a lot of vegetable oil, greasy taste and unpleasant smell, which m...

AI Technical Summary

Problems solved by technology

The Chinese Pharmacopoeia has collected soft capsules of vitamin D3. Although it can disperse the drug evenly, it also has inherent defects, such as long production cycle, complicated process, and poor stability of the preparation. For some special groups, it is inconvenient to swallow. Although the capsule can be cut into a small mouth, and the internal medicinal liquid can be squeezed out to take, but because there are more vegetable oils in the soft capsule, the taste is greasy, the smell is unpleasant, and it may even cause unbearable and spit out the medicine, which will not achieve the therapeutic effect.