Chinese medicinal composition for raising leucocytes and preparation method and application thereof

A technology for increasing white blood cells and compositions, which is applied in drug combinations, medical formulas, and extracellular fluid diseases, etc., can solve the problems of expensive hematopoietic factors, rebound phenomenon, fever, etc., to improve TCM symptoms and quality of life, Prevention and treatment of bone marrow suppression and the effect of increasing white blood cells

Active Publication Date: 2010-06-09
常熟雷允上制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these hematopoietic factors are expensive, have rebound phenomenon, and can cause bone pain, fever and other side effects

Method used

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  • Chinese medicinal composition for raising leucocytes and preparation method and application thereof
  • Chinese medicinal composition for raising leucocytes and preparation method and application thereof
  • Chinese medicinal composition for raising leucocytes and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of oral liquid formulation

[0025] 1. Weigh the raw Chinese medicinal materials: Astragalus 6kg, Polygonatum 6kg, Trichosanthes 6kg, Drynaria fortunei 6kg, Ligustrum lucidum 3kg, Epimedium 3kg.

[0026] 2. Decoct the above medicinal materials with 15 times the mass of water for 3 hours, filter, add water to the filter residue and decoct repeatedly, filter, combine the two filtrates, centrifuge to remove solid matter, take the supernatant and concentrate to obtain a clear Paste (relative density 0.8, temperature 59°C).

[0027] 3. Add 1kg sweetener, 2kg potassium sorbate, stir and add 30L water, 10wt% NaOH aqueous solution to adjust the pH value to 6-7, filter, fill, and sterilize.

Embodiment 2

[0028] Example 2 Preparation of granules

[0029] 1. Weigh the raw Chinese medicinal materials: Astragalus 30kg, Polygonatum 30kg, Trichosanthes 30kg, Drynaria fortunei 30kg, Ligustrum lucidum 15kg, Epimedium 15kg.

[0030] 2. Decoct the above medicinal materials with 14 times the mass of water for 3 hours, filter, add water and repeat the decoction of the filter residue, filter, combine the two filtrates, centrifuge to remove the solid matter, take the supernatant and concentrate to obtain a clear Paste (relative density 1.2, temperature 59°C).

[0031] 3. Add dextrin of the same quality as the clear cream and a sweetener of 5% by weight, and then go through drying, granulation, and granulation.

Embodiment 3

[0032] Example 3 Preparation of capsule formulation

[0033] 1. Weigh the raw Chinese medicinal materials: Astragalus 60kg, Polygonatum 60kg, Trichosanthes 60kg, Drynaria fortunei 60kg, Ligustrum lucidum 30kg, Epimedium 30kg.

[0034] 2. Decoct the above medicinal materials with 15 times the mass of water for 3 hours, filter, add water to the filter residue and decoct repeatedly, filter, combine the two filtrates, centrifuge to remove the solid matter, take the supernatant and concentrate to make a clear Paste (relative density 1.5, temperature 40°C).

[0035] 3. Add 8kg starch and mix well, granulate, sieving, drying, whole and filling.

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PUM

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Abstract

The invention discloses a Chinese medicinal composition for raising leucocytes, which is mainly prepared from the following raw material medicaments in part by weight: 6 to 60 parts of astragalus, 6 to 60 parts of Siberian solomonseal rhizome, 6 to 60 parts of Mongolian snakegourd root and 3 to 30 parts of epimedium herb. The invention also discloses a method for preparing the Chinese medicinal composition and application thereof in preparation of a medicament for treating leucopenia, improving immune function of an organism, promoting proliferation of marrow hematopoietic stem/progenitor cells, protecting hemopoietic microenvironment, repairing the damage and harm to marrow hematopoietic tissues by radioactive rays, preventing and controlling marrow suppression of chemoradiotherapy, promoting colony formation of granulocytes and monocytes, improving Chinese medicinal symptoms and living quality of patients with cancer, or promoting the recovery of patients with Qi-Yin deficiency.

Description

Technical field [0001] The invention relates to a Chinese medicinal composition for raising white blood cells and a preparation method and application thereof, and belongs to the field of Chinese medicine. Background technique [0002] The most common side effect of tumor radiotherapy and chemotherapy is bone marrow suppression, which is mainly manifested as the inhibition of the proliferation of hematopoietic stem cells. Due to the short life span of white blood cells, leukopenia is common in clinical manifestations. Bone marrow suppression limits the continuity of radiotherapy and chemotherapy, thereby affecting the efficacy of radiotherapy and chemotherapy. In recent years, domestic and foreign research and development of hematopoietic cytokines, such as G-CSF and GM-CSF, play a good auxiliary role in chemotherapy. However, these hematopoietic factors are expensive and rebound, which can cause side effects such as bone pain and fever. Traditional Chinese medicine has a cert...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P7/00
Inventor 徐振晔
Owner 常熟雷允上制药有限公司
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