Traditional Chinese medicine composition for treating leukopenia after chemoradiotherapy and preparation method thereof

A technique for leukopenia and composition, which is applied in the preparation of the traditional Chinese medicine composition and the field of traditional Chinese medicinal composition for treating leukopenia after radiotherapy and chemotherapy of malignant tumor, can solve the rebound phenomenon of patients, stimulate tumor growth, reduce the efficacy of chemotherapy, etc. problems, to achieve the effect of improving gastrointestinal function, safe clinical use, and increasing white blood cells

Active Publication Date: 2015-03-18
常州市肿瘤医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

General leucocyte-increasing Western medicines such as Lexogen, Bakelite, etc. have poor efficacy
Granulocyte colony-stimulating factor is used for leukopenia caused by chemotherapy, and the effect is quick, which solves the difficult problem of continuing chemotherapy due to leukopenia to a large extent,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example 1 Preparation of hard capsules

[0031] (1) Weigh each raw material decoction pieces according to the following weights: Codonopsis 1500g, Poria 1500g, Rhodiola 3000g, Wolfberry 1500g, Ligustrum lucidum 1500g, Fairy spleen 1000g, Cuscuta 1000g, Tangerine peel 1000g.

[0032] (2) Rhodiola, Xianling spleen, and tangerine peel are distilled to extract the volatile oil, and then 10 times the amount of β-cyclodextrin in the volatile oil of Rhodiola, Xianling spleen and tangerine peel, then add 3 times the amount of β-cyclodextrin After mixing with ethanol with a volume fraction of 40%, homogenize with a colloid mill for 15 minutes for inclusion. The homogenized solution after inclusion is refrigerated for 24 hours and then filtered. The filtered inclusion compound is dried at 40°C After crushing, set aside;

[0033] (3) Extract Codonopsis, Ligustrum lucidum and Lycium barbarum with a volume fraction of 95% ethanol. The weight of ethanol added is 4 times the total weight of...

Example Embodiment

[0039] Example 2 Preparation of powder

[0040] Weigh the raw materials according to the following weights: Codonopsis 1500g, Poria 1500g, Rhodiola 3000g, Lycium 1500g, Ligustrum lucidum 1500g, Xianling Spleen 1000g, Cuscuta 1000g, Tangerine Peel 1000g; After crushing each of the above-mentioned APIs, over 800g Mesh sieve, ready.

Example Embodiment

[0041] Example 3 Preparation of granules

[0042] (1) Weigh the raw materials according to the following weights: Codonopsis 1500g, Poria 1500g, Rhodiola 3000g, Wolfberry 1500g, Ligustrum lucidum 1500g, Fairy Spleen 1000g, Cuscuta 1000g, Tangerine Peel 1000g;

[0043] (2) Extract the volatile oil from Rhodiola rosea, Xianling spleen and tangerine peel, coat the volatile oil and crush it for use;

[0044] (3) Extract Codonopsis, Ligustrum lucidum, Lycium barbarum and Cuscuta seed with 95% ethanol in volume fraction. The weight of ethanol added is 4 times the total weight of the drug. Extract 3 times, extract 2 hours each time, combine the extracts, After filtering, the filtrate is concentrated to a clear paste with a relative density of 1.30 to 1.35 (55°C), and spray-dried to prepare a fine powder for use;

[0045] (4) Extract the spleen, rhodiola, dried tangerine peel and dregs of codonopsis, wolfberry, Ligustrum lucidum, Poria, and Cuscuta after the volatile oil is extracted twice wi...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating leukopenia after chemoradiotherapy and a preparation method thereof, which belong to the traditional Chinese medicine field. The traditional Chinese medicine composition comprises the following bulk drugs by weight part: 10-20 parts of Radix Codonopsis, 10-20 parts of Poria cocos, 15-45 parts of rhodiola root, 10-20 parts of wolfberry, 10-20 parts of ligustrum lucidum, 5-15 parts of herba epimedii, 5-15 parts of semen cuscutae and 5-15 parts of dried orange peel. The traditional Chinese medicine composition has the characteristics of invigorating spleen and benefiting qi, enriching essence and supplementing marrow, moderate drug nature, and no warmness and hotness; can effectively treat pathology factors such as dysfunctional internal organs and deficiency of essential qi, can improve symptoms of asthenia, soreness of loins and knees and loose stool, can protect bone marrow haematopoietic function, rises white blood cell and increases chemicotherapy completion rate.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating leukopenia after radiotherapy and chemotherapy, in particular to a Chinese medicine composition for treating malignant tumor leukopenia after radiotherapy and chemotherapy. The invention also relates to a preparation method of the Chinese medicine composition, which belongs to the field of traditional Chinese medicine . Background technique [0002] Tumor is one of the major diseases that endanger human health. According to the data released by WHO in 2003, in 2000, there were 10 million malignant tumor patients in the world, including 5.3 million males and 4.7 million females; 6.2 million deaths due to malignant tumors, accounting for 12% of the total deaths, this figure in developed countries Up to 25%. In developing countries, due to the acceleration of urbanization and changes in lifestyle and eating habits, the occurrence of tumors closely related to them will gradu...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P7/00A61P35/00
CPCA61K9/14A61K9/1652A61K36/076A61K36/296A61K36/344A61K36/39A61K36/41A61K36/638A61K36/752A61K36/815A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 吕新华
Owner 常州市肿瘤医院
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