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Traditional Chinese medicine composition for treating leukopenia after chemoradiotherapy and preparation method thereof

A technique for leukopenia and composition, which is applied in the preparation of the traditional Chinese medicine composition and the field of traditional Chinese medicinal composition for treating leukopenia after radiotherapy and chemotherapy of malignant tumor, can solve the rebound phenomenon of patients, stimulate tumor growth, reduce the efficacy of chemotherapy, etc. problems, to achieve the effect of improving gastrointestinal function, safe clinical use, and increasing white blood cells

Active Publication Date: 2015-03-18
常州市肿瘤医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

General leucocyte-increasing Western medicines such as Lexogen, Bakelite, etc. have poor efficacy
Granulocyte colony-stimulating factor is used for leukopenia caused by chemotherapy, and the effect is quick, which solves the difficult problem of continuing chemotherapy due to leukopenia to a large extent, but the price is expensive, and some patients have rebound phenomenon, fever, bone Pain and other side effects
Many scholars believe that the use of granulocyte colony-stimulating factor together with chemotherapy drugs can reduce the efficacy of chemotherapy and may stimulate the growth of certain tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 hard capsule

[0031](1) Weigh each raw material decoction piece according to the following weight: Codonopsis 1500g, Poria cocos 1500g, Rhodiola rosea 3000g, wolfberry fruit 1500g, privet fruit 1500g, fairy spleen 1000g, dodder seed 1000g, tangerine peel 1000g.

[0032] (2) Distill Rhodiola rosea, Xianlingpi, and tangerine peel to extract volatile oils, take β-cyclodextrin 10 times the amount of volatile oils from Rhodiola rosea, Xianlingpi, and tangerine peel, and then add 3 times the amount of β-cyclodextrin After mixing with ethanol with a volume fraction of 40%, use a colloid mill to homogenize for 15 minutes for clathrate, refrigerate the clathrate homogeneous solution for 24 hours, then filter, and dry the clathrate after filtration at 40°C After crushing, spare;

[0033] (3) Extract Codonopsis pilosula, Ligustrum lucidum, and Lycium barbarum with 95% ethanol, the weight of ethanol is 4 times the total weight of the drug, extract ...

Embodiment 2

[0039] The preparation of embodiment 2 powder

[0040] Take each bulk drug by the following weight: Codonopsis 1500g, Poria cocos 1500g, Rhodiola rosea 3000g, medlar fruit 1500g, Ligustrum lucidum 1500g, fairy spleen 1000g, dodder seed 1000g, tangerine peel 1000g; Mesh sieve, that is.

Embodiment 3

[0041] The preparation of embodiment 3 granules

[0042] (1) Weigh each raw material according to the following weight: Codonopsis 1500g, Poria cocos 1500g, Rhodiola rosea 3000g, medlar 1500g, Ligustrum lucidum 1500g, fairy spleen 1000g, dodder 1000g, tangerine peel 1000g;

[0043] (2) Extract volatile oil from Rhodiola rosea, fairy spleen, and tangerine peel, coat the volatile oil and crush it, and set aside;

[0044] (3) Extract Codonopsis pilosula, Ligustrum lucidum fruit, Lycium barbarum fruit and Cuscuta fruit with a volume fraction of 95% ethanol, and the weight of ethanol added is 4 times the total weight of the drug, and the extraction is performed 3 times, each time for 2 hours, and the extracts are combined, Filtrate, concentrate the filtrate to a clear paste with a relative density of 1.30-1.35 (55°C), spray dry to prepare a fine powder, and set aside;

[0045] (4) Extract the fairy spleen, rhodiola rosea, tangerine peel dregs, Codonopsis pilosula, Lycium barbarum,...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating leukopenia after chemoradiotherapy and a preparation method thereof, which belong to the traditional Chinese medicine field. The traditional Chinese medicine composition comprises the following bulk drugs by weight part: 10-20 parts of Radix Codonopsis, 10-20 parts of Poria cocos, 15-45 parts of rhodiola root, 10-20 parts of wolfberry, 10-20 parts of ligustrum lucidum, 5-15 parts of herba epimedii, 5-15 parts of semen cuscutae and 5-15 parts of dried orange peel. The traditional Chinese medicine composition has the characteristics of invigorating spleen and benefiting qi, enriching essence and supplementing marrow, moderate drug nature, and no warmness and hotness; can effectively treat pathology factors such as dysfunctional internal organs and deficiency of essential qi, can improve symptoms of asthenia, soreness of loins and knees and loose stool, can protect bone marrow haematopoietic function, rises white blood cell and increases chemicotherapy completion rate.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating leukopenia after radiotherapy and chemotherapy, in particular to a Chinese medicine composition for treating malignant tumor leukopenia after radiotherapy and chemotherapy. The invention also relates to a preparation method of the Chinese medicine composition, which belongs to the field of traditional Chinese medicine . Background technique [0002] Tumor is one of the major diseases that endanger human health. According to the data released by WHO in 2003, in 2000, there were 10 million malignant tumor patients in the world, including 5.3 million males and 4.7 million females; 6.2 million deaths due to malignant tumors, accounting for 12% of the total deaths, this figure in developed countries Up to 25%. In developing countries, due to the acceleration of urbanization and changes in lifestyle and eating habits, the occurrence of tumors closely related to them will gradu...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P7/00A61P35/00
CPCA61K9/14A61K9/1652A61K36/076A61K36/296A61K36/344A61K36/39A61K36/41A61K36/638A61K36/752A61K36/815A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 吕新华
Owner 常州市肿瘤医院
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