Process for drying 7-aminocephalosporanic acid

Abstract

The invention provides a process and equipment thereof for drying 7-aminocephalosporanic acid. The equipment comprises a horizontal tank, wherein the horizontal tank is provided with a stirring device, the upper part of the horizontal tank is provided with a solvent distilling pipe and a solvent reflow pipe, the lower part of the horizontal tank is provided with a discharging pipe; the other end of the solvent distilling pipe is arranged at the lower part of a condensation device, the lower end of the condensation device is provided with a collection and distribution device, the upper end of the condensation device is provided with a vacuum pump; and the solvent reflow pipe is connected with the upper part of the collection and distribution device, and the lower end of the collection and distribution device is provided with a water outlet. Because boiling points of organic solvent and water under the vacuum state are lowered, the temperature during the whole dehydrating and drying is lower, and the products can be effectively protected from being damaged; and meanwhile, because the temperature of the solvent is lower, the volatilization is reduced, the cost is lowered, and the health of operators is protected.

Description

technical field [0001] The invention relates to a 7-aminocephalosporanic acid drying process and equipment thereof. Background technique [0002] The abbreviation of 7-aminocephalosporanic acid is 7-ACA, which is an important intermediate for domestic production of cephalosporin antibiotics. [0003] At present, 7-ACA is usually produced by chemical method in China. Because 7-ACA produced by chemical method is crystallized, filtered and washed under the condition of solvent, its crystal form is relatively coarse and contains solvent. The content is about 20%, and it is easy to dry, so oven drying, double cone dryer drying and fluidized bed drying are often used to dry products. [0004] The 7-ACA produced by enzymatic method is crystallized in the water phase, the crystal form is relatively small, and the specific surface area is large, so the water content is large. After filtration, the water content is about 50%. The 7-ACA produced by enzymatic method adopts the traditio...

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Problems solved by technology

Due to the above reasons, the drying process and equipment of 7-ACA produced by enzymatic method have become a bottleneck technology that restricts the popularization and application of 7-ACA produced by enzymatic method

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