New natural hypericin antiviral drug

A technology of hypericin and hypericum, applied in antiviral agents, pharmaceutical formulas, plant raw materials, etc., can solve problems such as high cost, hypericin damage, and inability to process

Inactive Publication Date: 2010-06-23
4MICRO TECH COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Extracting hypericin (hypericin) with ethanol as a solvent is a relatively conventional method, but the content of hypericin (hypericin) in the extract is greatly affected by the extraction conditions, and the extract is easy to absorb moisture and stick into blocks. The hygroscopicity of the product has been solved by using agent, adjusting PH value, etc., but the content of hypericin (hypericin) in the product is only 0.7%, and hype

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 90% hypericin and 30% hypericin protect mice from influenza virus infection

[0024] Summary:

[0025] 70 male ICR mice with a weight of 17-19 g were randomly divided into 7 groups, namely blank control group, model control group, 90% hypericin low-dose group (1.5 mg·kg-1), 90% hypericin Sericin high-dose group (3.0mg·kg-1), 30% hypericin low-dose group (75mg·kg-1), 30% hypericin high-dose group (150mg·kg-1) and positive Control group (Tamiflu 10mg·kg-1). The mice in each group were given corresponding drugs daily from 1 day before virus infection, and observed the protective effect of 90% hypericin and 30% hypericin on the death protection of ICR mice infected with influenza virus, and compared with the positive drug -10mg · kg-1 Tamiflu for comparison.

[0026] The test results found that (1) 3.0mg kg-1 content of 90% hypericin has a higher death protection rate and prolongs life; (2) on the 4th day of A1 subtype influenza virus PR8 infection, each test In the dru...

Embodiment 2

[0096] Effects of hypericin and isohypericin on lung index of mice infected with influenza virus

[0097] Summary

[0098] Take 70 ICR mice of 17-19g, male, and randomly group them according to body weight, namely blank control group, model control group, 90% hypericin low-dose group, 90% hypericin high-dose group, 30% hypericin Hypericin low-dose group, 30% hypericin high-dose group and positive control group (Tamiflu). The mice in each group were given the corresponding drugs every day from 1 day before the virus infection, and observed the effect of 90% hypericin and 30% hypericin on the lung index of ICR mouse influenza virus infection, and compared with the positive drug -10mg· kg -1 Duffy for comparison.

[0099] The test results found that (1) after giving different concentrations of 90% hypericin, it can reduce the lung index value of influenza virus-infected mice and increase the lung index inhibition rate, 3.0mg·kg -1 The effect of hypericin with a content of 90%...

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Abstract

The invention takes hypericum perforatum P.E recently sold on the market as raw material, and uses a self-created molecular trapping technology to extract high-content hypericin with 30 percent to 100 percent of activity detectable component. The new natural hypericin drug with the 30 percent to 100 percent of hypericum has antiviral effect, the hypericin has a killing function on the broad-spectrum virus, and the photosensitive side effect of the hypericum is removed. The content of the hypericum is detected by HPLC to reach 30 percent to 100 percent. The preparation method of the invention is simple and quick, the product quality is even and stable, the large-scaled production is easy to realize, and the industrial production is met.

Description

(1) Technical field [0001] The present invention relates to a kind of common Hypericin perforatum extract which is currently sold in the market as a raw material, from which high-content hypericin is extracted, and the active component is more than 30%-100%. (2) Background technology [0002] Hypericum perforatum extract is currently one of the products favored by foreign manufacturers following Ginkgo biloba extract. It has been used as an antidepressant in foreign countries for more than a hundred years. And hypericin (hypericin) is the main antiviral active ingredient in Hypericum perforatum extract. In recent years, with the in-depth research on the anti-virus, anti-cancer and anti-depression mechanisms of Hypericum perforatum, it has become one of the hot topics of current research and development. For this reason, the extraction and purification process of the active ingredients of Hypericum perforatum extract has also generally received everyone's attention. [000...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K36/634A61P31/12C07C50/36C07C46/10
Inventor 黄肖辉马世界黄亮
Owner 4MICRO TECH COMPANY
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