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Medical composition for losing weight or treating hyperlipidemia

A technology for hyperlipidemia and composition, applied in the field of medicine, can solve the problems such as no report of synergistic effect of orlistat and pravastatin

Active Publication Date: 2011-05-18
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The literature did not report whether the combination of orlistat and pravastatin has a synergistic effect, but only concluded that the effect of the combined drug is better than that of pravastatin alone

Method used

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  • Medical composition for losing weight or treating hyperlipidemia
  • Medical composition for losing weight or treating hyperlipidemia
  • Medical composition for losing weight or treating hyperlipidemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The preparation of embodiment 1 compound tablet

[0011] Orlistat 150g

[0012] Rosuvastatin Calcium 2g

[0013] Microcrystalline Cellulose 45g

[0014] Starch 30g

[0015] 15% starch slurry appropriate amount

[0016] Magnesium Stearate 2.0g

[0017] Preparation process: It is prepared according to the conventional process of tablets.

Embodiment 2

[0018] The preparation of embodiment 2 compound tablet

[0019] Orlistat 150g

[0020] Rosuvastatin Calcium 10g

[0021] Compressible starch 90g

[0022] Lactose 50g

[0023] 15% starch slurry appropriate amount

[0024] Micronized silica gel 1.5g

[0025] Preparation process: It is prepared according to the conventional process of tablets.

Embodiment 3

[0027] a. Orlistat 120g

[0028] Hydroxypropyl Methyl Cellulose-4M 20g

[0029] Microcrystalline Cellulose 10g

[0030] 8% PVP in absolute ethanol solution

[0031] Magnesium Stearate 1.5g

[0032] Preparation process: Orlistat is passed through a 100-mesh sieve, hydroxypropyl cellulose-4M and microcrystalline cellulose are passed through a 80-mesh sieve, and the prescribed amount of orlistat, hydroxypropyl cellulose-4M, and microcrystalline cellulose are weighed Mix the ingredients evenly, add an appropriate amount of 8% PVP absolute ethanol solution to granulate, dry at 60°C, sieve the dry granules with a 16-mesh sieve, and add the prescribed amount of magnesium stearate to the dry granules.

[0033] b. Rosuvastatin calcium 4g

[0034] Sodium Carboxymethyl Cellulose 40g

[0035] Lactose 30g

[0036] 6% PVP in 95% ethanol solution 50g

[0037] Magnesium stearate 2g

[0038] Preparation process: Rosuvastatin calcium is passed through a 100-mesh s...

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Abstract

The invention discloses a medical composition for losing weight or treating hyperlipidemia, belonging to the field of medicines, and in particular relates to a medical composition containing orlistat or cetilistat and rosuvastatin calcium, wherein the composition is solid preparations such as compressed tablets, dispersible tablets, sustained release tablets, capsules, granules, and the like. In experiments, the medical composition containing the orlistat or the cetilistat and the rosuvastatin calcium is accidentally found to have obvious synergistic effect on the aspects of reducing the serum total cholesterol, the serum triglyceride and the low density lipoprotein cholesterin.

Description

technical field [0001] The invention relates to a pharmaceutical composition for losing weight or treating hyperlipidemia, which belongs to the field of medicine. Background technique [0002] With the development of the economy, the improvement of material living conditions and the unreasonable diet structure, obesity has spread like a plague in developed countries and developing countries with rapid economic development. my country's obesity patients have exceeded 70 million people (excluding childhood obesity), accounting for 5.4% of the total population. In Beijing, Shanghai and other big cities, nearly one-third of adults are overweight, becoming a high-incidence area for obesity. In the past ten years, the detection rate of childhood obesity has increased by an average of about 9% per year, which means that the number of obese children in my country will double in ten years. The World Health Organization officially confirmed obesity as a disease in 1997, and announce...

Claims

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Application Information

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IPC IPC(8): A61K31/505A61K31/365A61K31/536A61P3/06
Inventor 赵志全强红刚
Owner LUNAN PHARMA GROUP CORPORATION
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