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Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases and preparation method thereof

A technology of cardiovascular and cerebrovascular diseases and traditional Chinese medicine preparations, which is applied in the preparation of soft capsules and dripping pills, and in the field of traditional Chinese medicine preparations for the treatment of ischemic cardiovascular and cerebrovascular diseases. Acid damage and other problems, to achieve the effect of not easy hydrolysis, small dosage, fast dissolution rate

Inactive Publication Date: 2010-06-30
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Phenolic components mainly contain ferulic acid, which is poor in water solubility, soluble in hot water and ethanol, has low chemical stability, poor stability in aqueous solution, and decomposes faster when exposed to light. Ferulic acid is more damaging
[0006] But existing two kinds of dosage forms all have shortcomings and deficiencies in varying degrees, for example, the dosage of granules is large, and it is inconvenient to take; Storage will affect the curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation Process

[0018] Ginkgo biloba 1250g, kudzu root 1250g were crushed into the coarsest powder, added 10 times the amount of 80% ethanol and soaked at room temperature for 5 times, each time for 48 hours, and combined the soaking liquid. Ethanol is recovered under reduced pressure and concentrated, filtered, and the filtrate is passed through a macroporous adsorption resin AB-8 column, and the resin bed is washed with an aqueous hydrochloric acid solution of pH 7 with 10 times the volume of the column. Elution, collect the eluent, recover ethanol under reduced pressure, concentrate, vacuum dry to obtain dry extract, pulverize and set aside.

[0019] Chuanxiong powder 1250g was crushed into the coarsest powder, added 10 times the amount of 90% ethanol and soaked at room temperature for 5 times, each time for 48 hours, and combined the soaking solution. Ethanol was recovered under reduced pressure, concentrated, and separated into layers to obtain the Rhizoma C...

Embodiment 2

[0025] Preparation Process

[0026] Ginkgo biloba 1250g, kudzu root 1250g were crushed into the coarsest powder, added 2 times the amount of 40% ethanol and soaked twice at room temperature for 12 hours each time, and combined the soaking liquid. Ethanol was recovered under reduced pressure and concentrated, filtered, and the filtrate was passed through a macroporous adsorption resin D101 column, and the resin bed was washed with an aqueous hydrochloric acid solution of pH 2 with 3 times the volume of the column, and eluted with 30% ethanol with 2 times the volume of the column after washing the column , collect the eluent, recover ethanol under reduced pressure, concentrate, and vacuum-dry to obtain a dry extract, which is pulverized and set aside.

[0027] Chuanxiong 1250g was crushed into the coarsest powder, added 2 times the amount of 60% ethanol and soaked twice at room temperature for 12 hours each time, and combined the soaking solution. Ethanol was recovered under re...

Embodiment 3

[0033] Preparation Process

[0034] Ginkgo biloba 1250g, kudzu root 1250g were crushed into the coarsest powder, added 5 times the amount of 60% ethanol and soaked at room temperature 4 times, each time for 20 hours, and combined the soaking liquid. Ethanol is recovered under reduced pressure and concentrated, filtered, and the filtrate is passed through a macroporous adsorption resin AB-8 column, and the resin bed is washed with an aqueous hydrochloric acid solution of pH 3 with 5 times the volume of the column. Elution, collect the eluent, recover ethanol under reduced pressure, concentrate, vacuum dry to obtain dry extract, pulverize and set aside.

[0035] Chuanxiong 1250g was crushed into the coarsest powder, added 4 times the amount of 70% ethanol and soaked twice at room temperature for 20 hours each time, and combined the soaking solution. Ethanol was recovered under reduced pressure, concentrated, and separated into layers to obtain the Rhizoma Chuanxiong extract, wh...

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PUM

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Abstract

The present invention discloses a preparation method of Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases. The method comprises the following steps of: extracting and refining the ginkgo leaf and szechuan lovage rhizome to obtain the extract with higher content of active ingredient, adding the extract with pharmaceutic adjuvant with a ratio of 1 : 1 - 5 and 1 : 1 - 8, mixing uniformly, and preparing into soft capsule and pills respectively. The Chinese medicine preparation has significant effect on the treatment of ischemic cardiovascular and cerebrovascular diseases, coronary heart disease, angina pectoris, cerebral embolism, cerebral vasospasm and the like, no toxic and side-effect, the production technology is simple, and the quality control of product is convenient.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases, more specifically, a method for preparing soft capsules and dripping pills containing ginkgo leaf and chuanxiong extracts. Background technique [0002] Cardiovascular and cerebrovascular diseases are collectively referred to as cardiovascular diseases and cerebrovascular diseases. Generic name for disease. Diseases that occur in the arteries of the heart are called cardiovascular diseases, mainly including: myocardial infarction, coronary heart disease, myocardial infarction, etc. The lesions that occur in the cerebral arteries are called cerebrovascular diseases, mainly including cerebral hemorrhage, cerebral thrombosis, and cerebral embolism. Cardiovascular and cerebrovascular diseases are diseases with a high disability rate. Once su...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P9/10
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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