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Method for enriching and purifying folic acid in houseleek by macroporous absorbent resin

A technology of pore adsorption and resin, which is applied in the field of natural organic chemistry, can solve the problems of low extraction purity and low extraction rate, and achieve the effect of high extraction purity, large adsorption capacity, and convenient and quick extraction

Active Publication Date: 2012-10-17
HEILONGJIANG DINGHENGSHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low extraction purity, and provide a method for enriching and purifying folic acid in Vasong by using macroporous adsorption resin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: a kind of method utilizing macroporous adsorption resin to enrich and purify folic acid in Vasong, its steps are as follows:

[0027] (1) After crushing the dried pine, pass through a 60-mesh sieve, heat and reflux extraction with pH=4 acid water at a ratio of material:water=1:12 for 2 hours each time, and combine the extracts;

[0028] (2) Filtrate the vasone extract treated in (1), and dry under reduced pressure to obtain the initial extract in the form of an extract;

[0029] (3) dissolving the harvested extract in 75% ethanol for decolorization, and concentrating the decolorization solution to recover ethanol to obtain a crude extract of folic acid.

[0030] (4) The obtained folic acid extract is adsorbed on a macroporous adsorption resin chromatography column, and the macroporous resin used is the NKA-II type resin produced by Tianjin Nankai University;

[0031] (5) Use 10%, 20%, 30%, 40%, 50%|, 60%, 70%, 80%|, 90%, 95% ethanol to carry out gradient ...

Embodiment example 2

[0035] Implementation case 2: a kind of method utilizing macroporous adsorption resin to enrich and purify ursolic acid in cabbage, its steps are as follows:

[0036] (1) After crushing the dried vegetables, pass through a 10-mesh sieve, heat and reflux extraction with pH=4 acid water at a ratio of material:water=1:12 for 2 hours each time, and combine the extracts;

[0037] (2) Filtrate the vasone extract treated in (1), and dry under reduced pressure to obtain the initial extract in the form of an extract;

[0038] (3) dissolving the harvested extract in 75% ethanol for decolorization, and concentrating the decolorization solution to recover ethanol to obtain a crude extract of folic acid.

[0039] (4) The obtained folic acid crude extract is adsorbed with a macroporous adsorption resin, and the macroporous resin used is the D4006 type resin produced by Tianjin Nankai University;

[0040] (5) Carry out elution with 10%, 30%, 50%, 70%, 90% ethanol in macroporous adsorbent re...

Embodiment example 3

[0044] Implementation Case 3: A method for enriching and purifying folic acid in Vasong by using macroporous adsorption resin, the steps are as follows:

[0045] (1) After crushing the dried pine, pass it through an 80-mesh sieve, heat and reflux extraction with pH=4 acid water at a ratio of material:water=1:12, and extract twice for 2 hours each time, and combine the extracts;

[0046] (2) Filtrate the vasone extract treated in (1), and dry under reduced pressure to obtain the initial extract in the form of an extract;

[0047] (3) dissolving the harvested extract in 75% ethanol for decolorization, and concentrating the decolorization solution to recover ethanol to obtain a crude extract of folic acid.

[0048] (4) the obtained folic acid crude extract is adsorbed on a macroporous adsorption resin chromatography column, and the macroporous resin used is the NKA-9 type resin produced by Tianjin Nankai University;

[0049](5) Carry out gradient elution successively in the macr...

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Abstract

The invention relates to a method for enriching and purifying folic acid in houseleek by macroporous absorbent resin, which belongs to the field of natural organic chemistry. The invention is characterized in that the macroporous absorbent technology is used for separating and purifying the folic acid, the adsorption selectivity on the folic acid is good, both the adsorption and the desorption are fast, the adsorption capacity is large, the extraction is convenient and fast, the raw material sources are rich, the production cost is low, the separation effect is obvious, the extraction purity is high, the folic acid semi-finished products with the content higher than 35 percent and the folic acid finished products with the content higher than 98 percent can be obtained, and the defects of relatively low extraction rate and low extraction purity of the conventional method are overcome. The invention adopts the macroporous absorbent resin with the advantages of stable physicochemical property, large superficial area, high exchange speed, high mechanical strength, strong pollution resistance capability and good thermal stability, the folic acid can be selectively absorbed in the solution through physical absorption, and the invention has the advantages of fast absorption, fast desorption and large absorption capacity.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry and relates to a method for purifying folic acid, in particular to a method for enriching and purifying folic acid in vapine by using a macroporous adsorption resin. Background technique: [0002] Vasong: Chinese herbal medicine, [synonym] yesterday leaf lotus grass ("Tang Materia Medica"), rootless grass on the house ("Experience and Good Prescription"), Xiangtian grass ("Gengxin Jade Book"), tile flower ("Zaiyuan "Prescription"), stone lotus, lotus ("Fujian folk herbal medicine"), dry dripping ("Northeast medicine plant records"), cat's head grass, vata ("Hebei medicinal materials"), canopy grass ("Handbook of Chinese herbal medicines") "), tile frost, tile onion ("Sichuan Traditional Chinese Medicine"), sour tower, tasong, rabbit crutches, dry hanging soft-shelled turtle, stone tower flower, wolf's claw, sour liu ("Liaoning Economic Flora"), tile pagoda, tile lotus , Yansong, house pi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D475/04
Inventor 姚德坤姚德利闫峰姚航
Owner HEILONGJIANG DINGHENGSHENG PHARM CO LTD
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