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Plant extract and pharmaceutical composition for treating cough and preparation method thereof

A technology of alcohol extract and medicine, which is applied in the direction of medicine combination, medical formula, plant raw materials, etc., can solve the problem that there is no literature report on the effect of Corydalis stem and leaf extract in treating cough, and achieve good cough treatment with significant curative effect and low price. cheap effect

Active Publication Date: 2012-12-19
XIANGBEI WELMAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, so far, there is no literature report that Corydalis Corydalis stem and leaf extract has the effect of treating cough

Method used

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  • Plant extract and pharmaceutical composition for treating cough and preparation method thereof
  • Plant extract and pharmaceutical composition for treating cough and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Extract preparation

[0050] Preparation of Corydalis Corydalis Stem and Leaf Extract

[0051] Use 600ml 95% ethanol solution to carry out alcohol extraction to 60g Corydalis Corydalis stem and leaf powder, heat reflux for 3 hours, filter; Carry out decompression recovery solvent to the above-mentioned alcohol extract; Dry under reduced pressure to dryness, obtain Corydalis Corydalis stem and leaf extract .

Embodiment 2

[0052] Example 2 Preparation of Corydalis Corydalis Total Alkaloid Extract

[0053] Corydalis is crushed into coarse particles, and 5-10% Na 2 CO 3 or NaHCO 3 or NaOH soaked alkalization, and then extracted with 10% to 85% ethanol, the extract was concentrated under reduced pressure, and the concentrated solution was added with 1% to 10% HCl or 1% to 10% H 2 SO 4 Acidification, the acidification solution is subjected to resin column chromatography, and eluted with 0-90% ethanol, the eluate is concentrated under reduced pressure, and freeze-dried to obtain dry powder of total alkaloids.

Embodiment 3

[0054] Example 3 Antitussive effect of Corydalis stem and leaf extract on experimental cough

[0055] Experimental animals: male BALB / c mice, purchased from Shanghai Slack Experimental Animal Co., Ltd., weighing 20-26 g, were raised in an SPF grade animal room, 12h light / 12h dark, free access to feed and water.

[0056] Experimental materials: dextromethorphan, purchased from Shanghai Modern Pharmaceutical Co., Ltd.; stem and leaf extract of Corydalis Corydalis, prepared in Example 1.

[0057] Modeling method: use concentrated ammonia water to induce coughing, put the experimental mice into an inverted 500ml beaker, place a 50mg cotton ball in the beaker, inject 0.3ml of 25% concentrated ammonia water into the cotton ball with a syringe, and immediately record the mouse's Cough latency and the number of coughs within 3 minutes. Coughing performance of mice: abdominal contraction and mouth opening at the same time. Sometimes there can be a clear coughing sound, which requires...

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Abstract

The invention belongs to the technical field of pharmaceuticals, in particular to a plant extract and a pharmaceutical composition for treating cough and a preparation method thereof. The invention provides the plant extract for treating cough, which is of an alcohol extract of Corydalis stems and leaves. The invention also provides the pharmaceutical composition and the preparation method thereof. The plant extract has good function of treatment of cough, can be used for preparing antitussive, has the advantages of obvious curative effect, low cost, no addiction and the like; and simultaneously, the Chinese herb waste Corydalis stems and leaves can be changed into valuables from the waste, thereby not only bringing economic and source benefits but also providing a new choice for the treatment of cough.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a plant extract for treating cough, a pharmaceutical composition and a preparation method thereof. Background technique [0002] Cough is a protective airway reflex, which is a physiological reaction caused by an impulse transmitted to the medulla oblongata cough center after the respiratory tract is stimulated (such as inflammation, foreign body). Therefore, coughing is generally a beneficial action and is sometimes seen in healthy humans. In general, for mild and infrequent cough, as long as the sputum or foreign body is discharged, it can be relieved naturally, and there is no need to apply cough medicine. However, for those severe dry cough without phlegm, or severe cough with phlegm that is too frequent, it will not only increase the pain of the patient, affect rest and sleep, increase physical exertion, and even promote the development of the disease, resulti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P11/14A61P11/02A61P11/06A61P11/00A61P31/06A61P35/00A61K135/00A61K127/00
Inventor 俞强
Owner XIANGBEI WELMAN PHARMA CO LTD
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