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Methods and devices for intradermal injection

A delivery device and dermis technology, applied in the direction of subcutaneous injection devices, devices introduced into the body, needles, etc., can solve the problems of difficult implementation, unstable patients, lack of repeatable delivery, etc., and achieve the effect of preventing loss

Active Publication Date: 2010-07-28
SID TECH LLC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Lack of suitable devices for reproducible delivery to the epidermis and dermis limits widespread use of the intradermal route
Using traditional devices, intradermal injections are difficult, unstable and painful for the patient being treated

Method used

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  • Methods and devices for intradermal injection
  • Methods and devices for intradermal injection
  • Methods and devices for intradermal injection

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0121] Evaluation of the intradermal adapter was performed using machined adapter prototypes and single-use syringes. The adapter prototype was sized to accommodate a BD PLASTIPAK syringe with a volume of 1 ml, a 0.5" long needle, and a 28-gauge needle barrel in sliding relationship with the syringe. The needle barrel tip had a conventional Subcutaneous bevel. The injection procedure is as follows: 0.1 or 0.5 mL of WFI is drawn into the syringe; the syringe is placed in the adapter with the tip of the needle in the needle barrel channel; the adapter is applied to the intended injection site; the needle is inserted into the dermis ; inject the contained substance; and withdraw the needle and discard the syringe. Adjust the needle placement depth to place the centerline of the needle cannula at approximately 0.5 mm from the dermis surface. The length of the cannula in the dermis is set to 4.5 mm. WFI tested The volumes are 50 μl and 100 μl.

[0122] During routine intradermal i...

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PUM

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Abstract

Devices and methods for intradermal (ID) administration of diagnostic and therapeutic agents, vaccines and other compounds into the dermal layer of the skin are disclosed. The devices and the methods simplify the ID injection process and increase the consistency of the placement of the needle tip in the dermal space close to the skin surface allowing for a shallow cannula placement in the dermis.Furthermore, the devices and methods broaden the number of sites suitable for ID injection and make the ID injection possible with limited training.

Description

technical field [0001] The present invention relates to methods and devices for the intradermal administration of pharmaceuticals, vaccines and other compositions. In particular, an adapter device and needle assembly are described which may be attached to or form part of a drug delivery system, such as a syringe, to facilitate intradermal injection. Background technique [0002] Intradermal injections are used to deliver a variety of diagnostic and therapeutic compositions into patients. Substances can be injected intradermally for diagnostic tests, for example to determine the immune status of a patient against tuberculosis and the status of allergic diseases. Vaccines, drugs, and other compounds may also be delivered intradermally. In many cases, intradermal delivery is preferred because it generally requires smaller volume doses of the diagnostic or therapeutic compound than other delivery techniques. Intradermal injections are achieved by delivering substances into th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/32
CPCA61M5/425A61M2005/3247A61M5/3243A61M5/46A61M5/3271A61M5/3287
Inventor I·查尔斯
Owner SID TECH LLC
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