Polyethylene glycol-electrolyte oral solution

A polyethylene glycol and oral solution technology, applied in the direction of digestive system, metabolic diseases, inorganic active ingredients, etc., can solve the problem of inability to guarantee the osmotic pressure ratio of the solution, the inability to ensure the isotonicity of the intestinal tract, and uneven component ratios, etc. problem, to achieve the effect of good intestinal cleansing, shortened medication time, and quick onset of effect

Active Publication Date: 2012-05-02
BEIJING SHENGYONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The problem is that there is a loss of components when preparing the solution, resulting in uneven proportioning of the components; or because there is no accurate metering container, and the user's own problems deliberately increase or decrease the amount of water added, so that the solution of the final product There is a deviation in the concentration, and the osmotic pressure ratio of the solution cannot be guaranteed to be 1, and the isotonicity inside and outside the intestinal tract cannot be guaranteed, which not only affects the cleaning effect, but also may cause serious adverse reactions
[0016] At present, there are only a few hospitals in China that use "powder" for intestinal cleansing, and there are only a few who have the conditions to strictly control the preparation of drug solutions. Serious consequences of improper preparation

Method used

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  • Polyethylene glycol-electrolyte oral solution
  • Polyethylene glycol-electrolyte oral solution
  • Polyethylene glycol-electrolyte oral solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Take 59g of polyethylene glycol (PEG-4000), 1.47g of sodium chloride, 0.74g of potassium chloride, 1.69g of sodium bicarbonate, 5.69g of sodium sulfate (anhydrous), 0.02g of calcium sodium edetate, and 0.5g of sodium saccharin g. Pineapple essence 1ml;

[0055] Put polyethylene glycol, sodium chloride, potassium chloride, and sodium sulfate in the same container, add 50mL of water, heat to 40°C to dissolve, and stir, add 1g of activated carbon, heat to boiling, keep boiling for 10min, stop heating, When the temperature of the solution drops to 30°C, filter to remove the activated carbon, and wash the activated carbon layer with 50mL of water, and merge the washing liquid into the filtrate;

[0056] Dissolve sodium bicarbonate, calcium sodium edetate, and sodium saccharin in 50 mL of water;

[0057] Combine the above filtrate and solution, add pineapple essence, add water to a total volume of 1000ml, and mix well;

[0058] Sampling was taken to determine that the pH va...

Embodiment 2

[0061] Take 60g polyethylene glycol (PEG-4000), 1.1g sodium chloride, 0.8g potassium chloride, 1.7g sodium bicarbonate, 5.8g sodium sulfate (anhydrous), 0.5g disodium edetate, 0.02 stevioside g. Strawberry essence 2ml;

[0062] Put polyethylene glycol, sodium chloride, potassium chloride, and sodium sulfate in the same container, add 100mL of water, heat to 50°C to dissolve, and stir, add 0.5g of activated carbon, heat to boiling, keep boiling for 5min, stop heating , when the temperature of the solution drops to 25°C, filter to remove the activated carbon, and wash the activated carbon layer with 50mL of water, and merge the washing liquid into the filtrate;

[0063] Dissolve sodium bicarbonate, disodium edetate, and stevioside in 50 mL of water;

[0064] Combine the above filtrate and solution, add strawberry essence, add water to a total volume of 1000ml, and mix well;

[0065] Sampling was taken to determine that the pH value was 8.5, fine filtration was performed with a...

Embodiment 3

[0067] Take 59g of polyethylene glycol (PEG-4000), 1.5g of sodium chloride, 0.5g of potassium chloride, 2.0g of sodium bicarbonate, 5.9g of sodium sulfate (anhydrous), 0.1g of calcium sodium edetate, and 0.3g of sodium saccharin g. Banana essence 1.5ml;

[0068] Put polyethylene glycol, sodium chloride, potassium chloride, and sodium sulfate in the same container, add 100mL of water, heat to 45°C to dissolve, and stir, add 1g of activated carbon, heat to boiling, keep boiling for 5min, stop heating, When the temperature of the solution drops to 30°C, filter to remove the activated carbon, and wash the activated carbon layer with 100mL of water, and add the washing liquid to the filtrate;

[0069] Dissolve sodium bicarbonate, calcium sodium edetate, and sodium saccharin in 80 mL of water;

[0070] Combine the above filtrate and solution, add banana essence, add water to a total volume of 1000ml, and mix well;

[0071] Sampling was taken to determine that the pH value was 7.5,...

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Abstract

The invention provides polyethylene glycol-electrolyte oral solution, which comprises 59 to 60 grams of polyethylene glycol, 1.0 to 1.5 grams of sodium chloride, 0.5 to 1.0 gram of potassium chloride, 1.5 to 2.0 grams of sodium bicarbonate, 5.5 to 6.0 grams of sodium sulfate, 0.02 to 0.5 gram of edentate, 0.02 to0.5 gram of sweetener, 1 to 2 milliliters of flavoring essence and the balance of deionized water, wherein the solution is 1,000 milliliters. The polyethylene glycol-electrolyte oral solution is used in bowel cleansing and has the characteristics of quick response, safety, reliabilityand good cleansing effect. The oral solution is mainly suitable for cleansing bowels before colonoscopy, barium enema X-ray examination and gastrointestinal operation. The small-dose (about one eighth of a bowel cleansing dose) products of the oral solution can be used for treating chronic constipation.

Description

[0001] This application is a divisional application of Chinese patent application 200610056712.0. [0002] Original application date: 2006-3-6 [0003] Original application number: 200610056712.0 [0004] Invention-creation name of the original application: polyethylene glycol-electrolyte oral solution technical field [0005] The invention relates to a polyethylene glycol-electrolyte oral solution, which belongs to the field of pharmaceutical preparations. Background technique [0006] With the continuous improvement of people's living standards, the number of intestinal cancer and various intestinal diseases increases, and the number of intestinal operations and colonoscopy examinations is increasing day by day. [0007] According to preliminary investigations, only about 40,000 to 50,000 patients with colonic diseases in large hospitals in Beijing, Shanghai, and Tianjin need medical treatment, examination and treatment every year, while intestinal cleansing and pretreat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61K9/08A61P3/12A61P1/10A61K31/197A61K31/765A61K33/04A61K33/00
Inventor 陶忠华张红妹刘静朱莉亚
Owner BEIJING SHENGYONG PHARMA
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