Lipid nano particle preparation containing composite formed fatty acid and anthracyclines antitumor antibiotics and preparation method thereof

Abstract

The invention provides a lipid nano particle preparation containing a composite formed fatty acid and anthracyclines antitumor antibiotics and a preparation method thereof. The lipid nano particle preparation comprises a composite formed by the anthracyclines antitumor antibiotics and fatty acid, and phospholipid and lipoid of lipid nano particle carrier ingredients, wherein the weight ratio of the composite, the phospholipid and the lipoid is 1:1-10:1-10:1-1000.

Description

technical field The invention relates to the technical field of medicine, and specifically provides an anthracycline antitumor antibiotic fatty acid complex lipid nanoparticle preparation and a preparation method thereof that can be widely used in industrial production. Background technique Anthracycline anti-tumor antibiotics are a class of broad-spectrum anti-tumor drugs commonly used in clinic. They can produce a wide range of biochemical effects on the body and have strong cytotoxicity. The main mechanism of action is that drug molecules intercalate into DNA and inhibit the synthesis of nucleic acids. Anthracycline antineoplastic antibiotics are widely used in the treatment of various cancers, such as leukemia, lymphoma, breast cancer, lung cancer, liver cancer and many other solid tumors. Such antineoplastic drugs mainly include: Doxorubicin (ADM), Daunorubicin (DNR), Epirubicin (Epirubicin, EPI), Pirarubicin (THP-ADM), Aclacinomycin (Aclacinomycin, ACM) and the like. ...

AI Technical Summary

Problems solved by technology

2. The preparation process of liposome is complicated, and the cost of industrial production is relatively high, which makes its price very expensive. Clinical application of plastid preparation

However, the counter ion used in the method reported in the literature is hexadecyl phosphate, which is a chemical raw material used in the leather industry, which is highly toxic and cannot be used in humans.

In summary, it can be seen that there is no new preparation of anthracycline antitumor antibiotics with good stability, suitable for large-scale industrial production, simple preparation method, and low production cost.

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