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Gamma secretase modulators

A compound and pharmaceutical technology, applied in the field of γ-secretase modulators, can solve problems that have not yet been developed

Inactive Publication Date: 2010-09-01
SCHERING AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, the treatment of Alzheimer's disease is limited to symptomatic therapy using symptom-modifying agents represented by acetylcholinesterase inhibitors, and basic therapy for preventing the progression of the disease has not yet been developed

Method used

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  • Gamma secretase modulators
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Embodiment

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Abstract

A plurality of embodiments of the present invention provide a novel descending heterocyclic compound as gamma-secretase modulators, a method of preparing such compound, a medicinal composition containing one or more of such compounds, a method of preparing a medicinal preparation containing one or more of such compounds and a method of using the compound or medicinal composition for treating, presenting, restraining or improving one or more diseases related to a central nervous system.

Description

References to related applications This application claims the benefit of US Provisional Application Serial No. 60 / 954468, filed August 7, 2007. field of invention The present invention relates to certain heterocyclic compounds used as γ-secretase modulators (including inhibitors, antagonists, etc.), pharmaceutical compositions containing said compounds, and the use of the compounds and compositions to treat various diseases, including central Treatment of neurological disorders, such as neurodegenerative diseases, such as Alzheimer's disease, and other diseases involving amyloid deposition. They are particularly useful in reducing the production of amyloid beta (hereinafter referred to as Aβ), which is effective in the treatment of diseases caused by Aβ, such as Alzheimer's disease and Down's syndrome. Background of the invention Alzheimer's disease is a disease characterized by degeneration and loss of neurons, together with the formation of age spots and neurofibrilla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/60C07D417/10C07D419/10A61K31/4164A61P25/28
CPCC07D417/10C07D419/10C07D233/60A61P3/06A61P9/00A61P11/02A61P25/00A61P25/28A61P27/06A61P43/00
Inventor A·帕拉尼秦钧祝孝宏R·G·亚斯兰安M·D·麦布莱尔
Owner SCHERING AG