Thuja extract and application thereof in preparation of medicaments for preventing and treating neurodegenerative diseases
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An extract and technology of thuja, applied in the field of thuja extract and its application in the preparation of drugs for the prevention or treatment of neurodegenerative diseases, to achieve the effect of prolonging the time of paralysis and inhibiting apoptosis
Active Publication Date: 2010-09-22
SUN YAT SEN UNIV
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For example, so far there is no drug or treatment that can completely block the disease process of PD; tacrine, a drug for AD treatment, has been eliminated due to its l
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Embodiment 1
[0019] Embodiment 1: the preparation of thuja extract
[0020] Take 1 kg of thuja wood, process it into decoction pieces, add water to extract, add 10 times the volume of water each time, extract three times, heat reflux extraction, recover the solvent from the extract to obtain extract; add 5 times the volume of water to the extract, heat to fully dissolve, and Filtrate hot, concentrate the filtrate to a relative density above 1.05, and obtain the extract after degreasing; add ethanol to the extract after degreasing to make the alcohol mass concentration reach 50%, leave it for 10 hours, filter, recover the solvent from the filtrate, and obtain the thuja extract things.
Embodiment 2
[0021] Embodiment 2: the preparation of thuja extract
[0022] Take 1 kg of thuja wood, process it into sawdust, add ethanol for extraction, add 5 times the volume of ethanol each time, extract three times, leaching, recover the solvent from the extract to obtain an extract; add 20 times the volume of water to the extract, heat to fully dissolve, Filtrate while hot, concentrate the filtrate to a relative density above 1.05, and obtain the extract after degreasing; add ethanol to the extract after degreasing to make the alcohol concentration reach 80%, leave it for 1 hour, filter, recover the solvent from the filtrate, and obtain the thuja extract thing.
Embodiment 3
[0023] Embodiment 3: the preparation of thuja extract
[0024] Take 1 kg of thuja wood, process it into decoction pieces, add water to extract, add 50 mass% ethanol 10 times each time, extract three times, extract, recover solvent from the extract to obtain extract; add 12 times the volume of water to the extract, heat to fully dissolve , filtered while hot, and the filtrate was concentrated to a relative density above 1.05 to obtain the extract after degreasing; the extract after degreasing was added with ethanol to make the alcohol mass concentration to 70%, left for 50 hours, filtered, and the solvent was recovered from the filtrate to obtain the Cypress extract.
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Abstract
The invention discloses a thuja extract and application thereof in preparation of medicaments for preventing and treating neurodegenerative diseases. The thuja extract is prepared by the following steps of: taking thuja wood and processing the wood into pieces or wood shavings, adding a solvent for extraction, wherein the extraction solvent is water or ethanol or mixture of the water and the ethanol, and the solvent is 5 to 20 times weight of the thuja wood, performing leaching or heating reflux extraction, and recovering the solvent from the extract so as to obtain extractum; adding water accounting for 5 to 20 times weight of the extractum, heating to fully dissolve, filtering while hot, concentrating the filter liquor to the relative density of more than 1.05, and obtaining degreased extractum; and adding the ethanol into the degreased extractum so as to obtain the 50 to 80 percent alcohol, standing for 1 to 72 hours, filtering, and recovering the solvent from the filter liquor so as to obtain the thuja extract. The thuja extract is subjected to PC12 cell tests and anti-aging dementia nematode model tests, and the results prove that the thuja extract can obviously suppress apoptosis of the MPP+ mediated PC12 cells and prolong the nematode controlling time, has prevention and treatment effect on the Parkinson's disease and senile dementia, and can be used for preparing medicaments for preventing and treating the Parkinson's disease and senile dementia.
Description
technical field [0001] The invention relates to the application of thuja extract in medicines for preventing and treating Parkinson's disease and senile dementia. Background technique [0002] Neurodegenerative diseases (NDD) are a class of chronic, progressive neurological diseases. Although the lesion sites and causes of these diseases are different, the degeneration of nerve cells is their common denominator. Such diseases mainly include Parkinson's disease (PD), Alzheimer's disease (AD), chorea (Huntington disease) and amyotrophic lateral sclerosis (ALS), etc. Patients with neurodegenerative diseases often have symptoms such as memory loss, cognitive difficulties, dementia, movement balance disorders, and loss of motor ability, and the quality of life of patients is seriously reduced. In addition, the course of the disease is long and incurable, which brings great economic and psychological pressure to patients and their families. [0003] At present, most of the drug...
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