Thuja extract and application thereof in preparation of medicaments for preventing and treating neurodegenerative diseases

Abstract

The invention discloses a thuja extract and application thereof in preparation of medicaments for preventing and treating neurodegenerative diseases. The thuja extract is prepared by the following steps of: taking thuja wood and processing the wood into pieces or wood shavings, adding a solvent for extraction, wherein the extraction solvent is water or ethanol or mixture of the water and the ethanol, and the solvent is 5 to 20 times weight of the thuja wood, performing leaching or heating reflux extraction, and recovering the solvent from the extract so as to obtain extractum; adding water accounting for 5 to 20 times weight of the extractum, heating to fully dissolve, filtering while hot, concentrating the filter liquor to the relative density of more than 1.05, and obtaining degreased extractum; and adding the ethanol into the degreased extractum so as to obtain the 50 to 80 percent alcohol, standing for 1 to 72 hours, filtering, and recovering the solvent from the filter liquor so as to obtain the thuja extract. The thuja extract is subjected to PC12 cell tests and anti-aging dementia nematode model tests, and the results prove that the thuja extract can obviously suppress apoptosis of the MPP+ mediated PC12 cells and prolong the nematode controlling time, has prevention and treatment effect on the Parkinson's disease and senile dementia, and can be used for preparing medicaments for preventing and treating the Parkinson's disease and senile dementia.

Description

technical field [0001] The invention relates to the application of thuja extract in medicines for preventing and treating Parkinson's disease and senile dementia. Background technique [0002] Neurodegenerative diseases (NDD) are a class of chronic, progressive neurological diseases. Although the lesion sites and causes of these diseases are different, the degeneration of nerve cells is their common denominator. Such diseases mainly include Parkinson's disease (PD), Alzheimer's disease (AD), chorea (Huntington disease) and amyotrophic lateral sclerosis (ALS), etc. Patients with neurodegenerative diseases often have symptoms such as memory loss, cognitive difficulties, dementia, movement balance disorders, and loss of motor ability, and the quality of life of patients is seriously reduced. In addition, the course of the disease is long and incurable, which brings great economic and psychological pressure to patients and their families. [0003] At present, most of the drug...

AI Technical Summary

Problems solved by technology

For example, so far there is no drug or treatment that can completely block the disease process of PD; tacrine, a drug for AD treatment, has been eliminated due to its liver toxicity and obvious drug interactions, and donepezil (donepezil) The main side effects of rivastigmine and galantamine are nausea, vomiting, diarrhea and anorexia.

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