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Artemisia rupestris L pill and production method and application thereof

A production method and technology of dripping pills, which are applied in the direction of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of hazards and low production costs, and achieve stable and reliable processes, simple equipment, and save production costs. Effect

Active Publication Date: 2010-09-22
XINJIANG QUANAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented new type medicine called Yingoubing Dandy (Janus) droplets made from an extract containing both citrulline hydrochloride and quercitrinone was found promising results against inflammations associated with joint pain or swelling due to degradeed cartilage tissue. These tiny particles were then extracted out of it along with certain chemical compounds like malaria securities. They could help treat diseases related to these conditions more effectively than existing drugs alone.

Problems solved by technology

This patents discusses various methods used to reduce the risk of relapsive lymphocyte mediated (ML) syndrome caused by rheuma fever and rhumans who cause debilitating conditions like RA. However, current therapies target primarily against these causes rather poor outcomes despite being able to effectively lower down circulatory levels associated with this condition. There remains a challenge for scientists working towards finding novel ways to improve existing remedy options while maintaining efficacy over time.

Method used

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  • Artemisia rupestris L pill and production method and application thereof
  • Artemisia rupestris L pill and production method and application thereof
  • Artemisia rupestris L pill and production method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]Example 1: Mix the same amount of Hypericum perforatum and Artemisia perforatum medicinal materials, grind them into coarse powder, add 8 times the amount of 60% ethanol to reflux and extract twice, each time for 1 hour, combine the extracts, filter the extracts, let cool, Centrifuge, concentrate the supernatant under reduced pressure to 0.20g crude drug per 1ml concentrated solution, pass through one or more macroporous adsorption resins in HPD100, HPD100A, HPD400 and HPD400A, the diameter-to-height ratio of the resin is 1:4, and the adsorption Speed ​​1.0BV / h, elution speed 1.0BV / h, first use 3BV water to elute at a flow rate of 3BV / h to wash away water-soluble impurities, then elute 4BV with 30% ethanol, elute 4BV with 70% ethanol, collect 30% and 70% ethanol eluent, ethanol is recovered under reduced pressure and concentrated to a clear paste with a relative density of 1.22 to 1.25 (60°C), and then dried in a vacuum oven (temperature 60°C) to obtain extract powder (10...

Embodiment 2

[0026] Example 2: Mix the same amount of Hypericum perforatum and Artemisia perforatum medicinal materials, grind them into coarse powder, add 10 times the amount of 70% ethanol to reflux and extract for 3 times, each time for 1.5 hours, combine the extracts, filter the extracts, let cool, Centrifuge, concentrate the supernatant under reduced pressure to contain 0.22g of crude drug per 1ml concentrated solution, pass one or more macroporous adsorption resins in HPD100, HPD100A, HPD400 and HPD400A, the resin diameter-to-height ratio is 1:7, and absorb Speed ​​2.0BV / h, elution speed 2.0BV / h, first use 4BV water to elute at a flow rate of 5BV / h to wash away water-soluble impurities, then elute 5BV with 30% ethanol, elute 5BV with 70% ethanol, collect 30% and 70% ethanol eluent, ethanol is recovered under reduced pressure and concentrated to a clear paste with a relative density of 1.22 to 1.25 (60°C), and then dried in a vacuum oven (temperature 60°C) to obtain extract powder (100...

Embodiment 3

[0027] Example 3: Mix the same amount of Hypericum perforatum and Artemisia perforatum medicinal materials, grind them into coarse powder, add 12 times the amount of 70% ethanol to reflux extraction for 3 times, each time for 2 hours, combine the extracts, filter the extracts, let cool, Centrifuge, concentrate the supernatant under reduced pressure to 0.25g of crude drug per 1ml concentrated solution, pass through one or more macroporous adsorption resins in HPD100, HPD100A, HPD400 and HPD400A, the diameter-to-height ratio of the resin is 1:10, and absorb Speed ​​3.0BV / h, elution speed 3.0BV / h, first use 5.0BV water to elute at a flow rate of 6.0BV / h to wash away water-soluble impurities, then elute 6.0BV with 30% ethanol, and elute with 70% ethanol 6.0BV, collect 30% and 70% ethanol eluent, recover ethanol under reduced pressure and concentrate to a clear paste with a relative density of 1.22 to 1.25 (60°C), and then dry it in a vacuum oven (temperature 60°C) to obtain Cream ...

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PUM

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Abstract

The invention relates to an artemisia rupestris L pill and a production method and application thereof, the method comprises the following steps: step I: CommonSt.John'swortHerb and artemisia rupestris L with equal quantity are mixed and are crushed into coarse powder, ethanol is added for backflow extraction, the extracting solution is filtered, cooled and centrifuged, and then supernate is concentrated; step II: the concentrated solution is purified by macroporous absorption resin, and effluent liquid is collected in different segments, the effluent liquid is concentrated and is dried to obtain extract powder for spare; step III: the dry extract powder is mixed with polyethylene glycol according to proportion, the mixture is melted by heating, and then pills are produced by dropping. The process in the invention is stable and reliable, the contents of effective ingredients in the pills are stable; the invention solves the problem that residual organic solvent caused by the extraction of organic solvents such as petroleum ether, ethyl acetate and the like is harm to human bodies. Compared with the prior art, the method in the invention is suitable industrial production; the artemisia rupestris L pill obtained in the invention has obvious anti-inflammatory analgesic activities which are proved by experiments in pharmacodynamics and is used for treatment of rheumatism and rheumatoid arthritis.

Description

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Claims

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Application Information

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Owner XINJIANG QUANAN PHARMA
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