Pharmaceutical containing HIF-1alpha alpha and HIF-2alpha alpha expression inhibitor
A technology of HIF-1 and HIF-2, applied in the direction of medical preparations containing active ingredients, drug combinations, genetic material components, etc., can solve the problems that have not been reported
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[0130] Examples are given below to further describe the present invention in detail, but the present invention is not limited thereto.
preparation example 1
[0131] Preparation example 1: Injection for intravitreal administration
[0132] Injections for intravitreal administration shown below were prepared according to conventional methods.
[0133] HIF-1α siRNA:
[0134] Sense-GGA ACC UGA UGC UUU AAC UTT (SEQ ID NO.5) 1mg
[0135] Antisense-AGU UAA AGC AUC AGG UUC CTT (SEQ ID NO.11) 1mg
[0136] HIF-2α siRNA:
[0137] Sense-CGG AGG UGU UCU AUG AGC UTT (SEQ ID NO.9) 1mg
[0138] Antisense-AGC UCA UAG AAC ACC UCC GTC (SEQ ID NO.15) 1mg
[0139] Sodium dihydrogen phosphate 0.1g
[0140] Sodium chloride 0.9g
[0141] Appropriate amount of sodium hydroxide
[0142] Appropriate amount of sterile purified water
[0143] Total 100mL
[0144] (pH7)
preparation example 2
[0145] Formulation example 2: Injection for intravitreal administration
[0146] Injections for intravitreal administration shown below were prepared according to conventional methods.
[0147] HIF-1α siRNA:
[0148] Sense-GGG UAA AGA ACA AAA CAC A TT (SEQ ID NO.6) 0.1mg
[0149] Antisense - UGU GUU UUG UUC UUU ACC C TT (SEQ ID NO.12) 0.1mg
[0150] HIF-2α siRNA:
[0151] Sense-GGU UUU GUU GCU AGC CCU U TT (SEQ ID NO.10) 0.1mg
[0152] Antisense-AAG GGC UAG CAA CAA AAC C TT (SEQ ID NO.16) 0.1mg
[0153] Sodium dihydrogen phosphate 0.1g
[0154] Glycerin 2.5g
[0155] Appropriate amount of sodium hydroxide
[0156] Appropriate amount of sterile purified water
[0157] Total 100mL
[0158] (pH 7)
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