Medicinal composition for treating respiratory disease

The technology of a composition and respiratory tract is applied in the field of pharmaceutical compositions for administration by inhalation of ambroxol hydrochloride and tetrabutyl phenolic aldehyde, and can solve the problems of large adverse reactions, slow onset of oral preparations and the like

Active Publication Date: 2010-12-01
北京华禧联合科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used dosage forms of ambroxol hydrochloride include oral solution, tablet, capsule, sustained-release capsule, injection, aerosol, etc. Oral preparations have slow onset of action, full-body effects, and large adverse reactions, but ar

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: 50 grams of ambroxol hydrochloride and 50 grams of tyloxapol were added in 560 grams of ethanol and mixed uniformly, 22 grams of Tween-80, 10 grams of glycerol and 8 grams of PVP (k15) were added and stirred to obtain a feed liquid. Feed liquid is packed by every bottle containing 500 mg of ambroxol hydrochloride, sealed, every bottle is filled with 2 gram of carbon dioxide and 3 gram of dimethyl ether (DME), bath inspection, packing, inspection.

Embodiment 2

[0023] Embodiment 2: 50 grams of ambroxol hydrochloride and 100 grams of tyloxapol are added in 550 grams of ethanol and 120 grams of propylene glycol and mixed uniformly, add 10 grams of PVP (k30) and 20 grams of glycerin, stir to obtain feed liquid. Feed liquid is packed by every bottle containing 500 mg of ambroxol hydrochloride, sealed, every bottle is filled with 4 grams of dichlorofluoromethane (CFC-11), bath inspection, packaging, inspection.

Embodiment 3

[0024] Embodiment 3: 50 grams of ambroxol hydrochloride and 150 grams of tyloxapol are added in 540 grams of water and 100 grams of propylene glycol and mixed uniformly, add 30 grams of Tween-80, 25 grams of spar-80 and 5 grams of peppermint oil, stir well Get liquid. Feed liquid is packed by every bottle containing 500 mg of ambroxol hydrochloride, sealed, every bottle is filled with 3 grams of dichlorodifluoromethane (CFC-12), bath inspection, packaging, inspection.

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PUM

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Abstract

The invention relates to a medicinal composition for treating respiratory disease, in particular to a medicinal composition with synergy for sucking administration of ambroxol hydrochloride and tetrabutyl phenolic aldehyde. A medicament is administrated by sucking and directly enters an air passage, so the suction rate is high, the local has high concentration, low using amount and low adverse reaction, and the medicament can effectively promote the discharge of sputum of a patient and remarkably improve the application compliance of the patient.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating respiratory diseases, in particular to a pharmaceutical composition with synergistic effect of ambroxol hydrochloride and tyxapol administered via inhalation. Background technique [0002] Diagnosis of respiratory diseases is mainly manifested by the four major symptoms of "cough, phlegm, wheezing, and inflammation". Cough is a protective physiological reflex that can promote the discharge of sputum. At the same time, it is also a pathological reaction that can be stimulated by inflammatory secretions such as sputum and foreign objects. Excessive cough vibration can also damage lung tissue, so it is necessary to expel sputum. Liquid is also the main method of relieving cough; asthma is mostly caused by bronchitis spasm, and bronchospasm can reflexively cause increased respiratory secretions, that is, sputum, and excessive secretion blockage can further aggravate bronchospasm; the pathol...

Claims

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Application Information

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IPC IPC(8): A61K31/775A61K31/137A61K9/12A61P11/12A61P11/10A61P11/06
Inventor 胡淑娟王波毕华张志芳
Owner 北京华禧联合科技发展有限公司
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