Novel dosage form containing albendazole and application and preparation method thereof

A technology of albendazole and new dosage forms, applied in the field of new dosage forms containing albendazole, can solve the problems of slow disintegration, poor drug compliance, inconvenient swallowing of compound albendazole ordinary tablets, etc., and achieve absorption Fast, easy to take, and the effect of improving the taste of the drug

Inactive Publication Date: 2010-12-22
SICHUAN BAOSHENGKANG PHARMA
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a compound albendazole common tablet that can overcome the shortcomings of inconvenient swallowing, poor drug compliance, and slow disintegration in the prior art. Fast, high bioavailability, new dosage form with good taste and its application and preparation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel dosage form containing albendazole and application and preparation method thereof
  • Novel dosage form containing albendazole and application and preparation method thereof
  • Novel dosage form containing albendazole and application and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The compound albendazole granule of this embodiment is made up according to the following formula, and the weight unit in the formula is g, which can be made into 5000g granule. The preparation method adopts the following process steps:

[0023] 1. Granulation: Weigh 600g albendazole, 3600g pyrantel pamoate, add lactose 200g, stevioside 250g, dextrin 1000g and pass through a 100 mesh sieve, place in a high-speed mixing granulator (rotating speed: 20r / min), stir for 30 minutes, fully mix and disperse evenly, start the chopping motor and use 80% ethanol to make wet granules;

[0024] 2. Drying: spread the above wet granules on a tray, and dry them in an oven at 80°C for 2 hours;

[0025] 3. Grain sizing: After drying, pass through the No. 1 sieve (12-14 mesh) of the oscillating granule to grind the large particles, and then pass through the No. 4 sieve (60 mesh) to remove fine particles and fine powder.

[0026] 4. Packing: The above-mentioned granules are sealed and p...

Embodiment 2

[0028] The present embodiment's compound albendazole granule is made up of following formula, and the weight unit in the formula is g, can make 6000g granule; Preparation method is as follows:

[0029] 1. Granulation: take by weighing 1100g albendazole, 4400g pyrantel pamoate, add glucose 500g, microcrystalline cellulose 200g, citric acid 300g and cross 80 mesh sieves, place high-speed mixing granulator (rotating speed For: 15r / min), stir for 30 minutes, fully mix and disperse evenly, start the chopping motor and use 70% ethanol to make wet granules;

[0030] 2. Drying: spread the above-mentioned wet granules on a plate, and dry them in an oven at 80°C for 2 hours;

[0031] 3. Grain sizing: After drying, pass through the No. 1 sieve (12-14 mesh) of the oscillating granule to grind the large particles, and then pass through the No. 4 sieve (60 mesh) to remove fine particles and fine powder.

[0032] 4. Packing: The above-mentioned granules are sealed and packed and stored in a...

Embodiment 3

[0034] The present embodiment compound albendazole granule is made up of following formula, and the weight unit in the formula is g, can make 5000g granule; Preparation method is as follows:

[0035] 1. Granulation: take by weighing 1600g of albendazole, 3200g pyrantel pamoate, add 800g of dextrin, 400g of starch, 200g of tartaric acid, 200g of cyclamate and cross a 70 mesh sieve, place in a high-speed mixing granulator ( Rotation speed: 20r / min), stir for 25 minutes, fully mix and disperse evenly, start the chopping motor and use 30% ethanol to make wet granules;

[0036] 2. Drying: spread the above wet granules on a plate, and dry them in an oven at 60°C for 3 hours;

[0037] 3. Grain sizing: After drying, pass through the No. 1 sieve (12-14 mesh) of the oscillating granule to grind the large particles, and then pass through the No. 4 sieve (60 mesh) to remove fine particles and fine powder.

[0038] 4. Packing: The above-mentioned granules are sealed and packed and stored ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a novel dosage form containing albendazole and application and a preparation method thereof. The novel dosage form mainly takes the mixture of albendazole and pamoic acid pyrantel as a medicinal composition, and an excipient and a flavoring agent are added to the medicinal composition to be made into granules. The novel dosage form contains 500-800 parts of medicinal composition, 40-120 parts of excipient and 50-100 parts of flavoring agent in parts by weight. The granules have the advantages of good drug disperse states, short disintegration time, rapid drug dissolution, rapid absorption, high bioavailability and the like and are convenient to take. The drug mouthfeel can be regulated according to the fondness of children, such as the apple taste, the lemon taste and the like. The novel dosage form is especially suitable for children, patients with special conditions and patients who are difficult to swallow. However, the children are parasitic disease susceptible populations but have poorer drug compliance. In order to increase the drug compliance of the children and improve the drug mouthfeel and the taking mode, designing the dosage form into the granules is extremely necessary. The invention also makes the orally taken dosage form of the compound albendazole granules diversified and simultaneously provides more selections for clinician and patient medications.

Description

technical field [0001] The invention relates to a new dosage form containing albendazole and its application and preparation method. Background technique [0002] Parasitic disease is a public health problem that seriously affects the health of the people and affects social and economic development. For a long time, under the leadership of governments at all levels, various localities have carried out comprehensive prevention and control of key parasitic diseases according to local conditions, and have achieved remarkable results. The national survey on important human parasitic diseases completed in 2004 showed that the infection rate of soil-transmitted nematodes decreased by 63.65% compared with 1990, and the number of infected people decreased by nearly 400 million. However, due to the constraints of social, economic and natural environment factors, the current national helminth infection rate is 21.38%, and there are still 11 provinces, autonomous regions, and municipa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/506A61K31/4184A61K9/16A61P33/10
Inventor 唐楷
Owner SICHUAN BAOSHENGKANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap