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Finger-print quality determination method on wuji powder preparation and intermediate thereof

A fingerprint and detection method technology, applied in the field of fingerprint quality determination of Wujisan preparations and their intermediates, can solve the problems of no quality control, can not meet the requirements of quality control, single dosage form, etc., to achieve high precision, Improve quality and curative effect control, good reproducibility effect

Active Publication Date: 2011-10-05
JIUZHITANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, Wujisan preparations on the market only have Wuji pills, Wujisan granules and Wujisan wine, and the dosage forms are relatively single.
The quality control of Wujisan preparations in the existing drug standards only includes identification and inspection items, which can no longer meet the requirements for quality control
In literature reports, only Li Ruocun et al. conducted TLC identification of ephedra, Atractylodes macrocephala, Magnolia officinalis, Angelica, and Atractylodes atractylodes in Wuji pills (Li Ruocun et al., Hunan Journal of Traditional Chinese Medicine, 1997, 13(2):43), this kind of thin-layer identification is only a qualitative quality control, and there is no quantitative quality control

Method used

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  • Finger-print quality determination method on wuji powder preparation and intermediate thereof
  • Finger-print quality determination method on wuji powder preparation and intermediate thereof
  • Finger-print quality determination method on wuji powder preparation and intermediate thereof

Examples

Experimental program
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Effect test

Embodiment 1 5

[0043] The preparation of embodiment 1 Wuji Sanjiu intermediate, preparation

[0044] Take 80g of Poria cocos, 60g of angelica, 60g of white peony, 60g of bellflower, 60g of atractylodes (stir-fried with bran), 60g of Angelica dahurica, 60g of Magnolia officinalis (made from ginger), 60g of tangerine peel, 60g of citrus aurantium (stir-fried with bran), 60g of ephedra, pinellia (made of pinellia). ) 60g, cinnamon twig 60g, licorice 60g, Chuanxiong 30g, dried ginger 30g, the above fifteen flavors, crushed into coarse powder, use white wine as a solvent, soak for 10-15 days, slowly percolate, and obtain the intermediate liquid.

[0045] Take another 2000g of sucrose from the collected filtrate to make syrup, wait until warm, add it to the above filtrate, let it stand, filter, and make about 17500g, to get final product.

Embodiment 2 5

[0046] The preparation of embodiment 2 Wuji powder

[0047] Take 90g Poria, 90g Angelica, 90g Paeoniae Alba, 180g Bellflower, 240g Atractylodes (stir-fried with bran), 90g Angelica dahurica, 120g Magnolia officinalis (made from ginger), 150g tangerine peel, 150g Citrus aurantii (stir-fried with bran), 120g ephedra, and Pinellia fragrans 90g, Guizhi 150g, Licorice 90g, Chuanxiong 60g, Dried Ginger 90g, above fifteen flavors, Poria cocos and Paeoniae Alba, crushed, sieved through 80 mesh to get fine powder, set aside; The volatile oils were extracted from twigs, dried ginger, Angelica dahurica, Angelica, Chuanxiong and Magnolia officinalis (made from ginger), clathrated with β-CD, left for more than 12 hours, filtered, and dried at low temperature to obtain clathrates for later use. The medicinal residues and medicinal liquid after oil extraction are decocted with Platycodon grandiflorum, licorice, ephedra and pinellia twice, each time for 2 hours, and the obtained water extract...

Embodiment 3 5

[0048] The preparation of embodiment 3 Wujisan granules

[0049] Take 150g Poria, 150g Angelica, 150g White Peony, 300g Bellflower, 400g Atractylodes (stir-fried with bran), 150g Angelica dahurica, 200g Magnolia officinalis (made from ginger), 250g tangerine peel, 250g Citrus aurantium (stir-fried with bran), 200g Ephedra, and 150g Pinellia , 250g cinnamon sticks, 150g licorice, 100g Chuanxiong, 150g dried ginger, the above fifteen flavors, atractylodes (stir-fried with bran), orange peel, tangerine peel, cinnamon sticks, dried ginger, angelica, angelica, chuanxiong and magnolia (made from ginger) nine The volatile oil was extracted with flavor, clathrated with β-CD, placed for more than 12 hours, filtered, and dried at low temperature to obtain clathrates for later use. The medicinal dregs and medicinal liquid after oil extraction are decocted twice with platycodon grandiflorum, white peony root, licorice, ephedra, pinellia (made), and poria cocos for 2 hours each time, and t...

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Abstract

The invention discloses a finger-print quality determination method on wuji powder preparation and intermediate thereof. The finger-print quality determination method includes the following steps: quantitative wuji powder preparation or intermediate thereof is weighed, at least one of solvents of water, methyl alcohol or ethyl alcohol is used for extraction, constant volume is carried out, so as to obtain test solution; the test solution is sucked and injected into a liquid chromatograph, and high efficiency liquid chromatography and gradient elution are adopted for carrying out determination, so as to obtain the finger-print of wuji powder preparation or intermediate thereof; wherein the chromatographic conditions of the high efficiency liquid chromatography include that the filler of chromatographic column is octadecylsilane chemically bonded silica, mobile phase A is methyl alcohol, mobile phase B is phosphoric acid aqueous solution, the volume ratio of the mobile phase A and the mobile phase B is gradually increased along with time, and detection wavelength is 285-305nm. The invention has the characteristics that method is simple and stable, has high precision and good reproducibility and is easy to grasp.

Description

technical field [0001] The invention relates to a method for measuring the quality of fingerprints of traditional Chinese medicines, in particular to a method for measuring the quality of fingerprints of Wujisan preparations and intermediates thereof. Background technique [0002] At present, due to various reasons, the quality standards of traditional Chinese medicine are not perfect. Confused or even counterfeit products of traditional Chinese medicine are often seen in the market, seriously endangering people's medication safety. Therefore, it has become a consensus to strengthen the research on the quality of traditional Chinese medicine and formulate a more perfect, more accurate and more authoritative method for evaluating the quality of traditional Chinese medicine. [0003] The current standard for quality evaluation of traditional Chinese medicine is to identify and measure one or several active ingredients, active ingredients or index ingredients by means of spect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P1/14A61P1/08A61P15/00G01N30/02G01N30/36
Inventor 刘春海张妮瑜朱丽陈亮
Owner JIUZHITANG
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