Double-nasal cavity continuous nasal administration device and using method thereof

A drug delivery device and dual nasal cavity technology, applied in the field of medical devices, can solve the problems of difficulty in effectively reaching the nasal cavity, only lasting 20-30 minutes, and entering the upper respiratory tract, etc., to achieve the effect of improving the effective utilization rate

Inactive Publication Date: 2011-02-23
刘新峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current traditional nasal drug delivery method has great deficiencies, which limit its clinical application
The traditional nasal drip method is also the most classic method, and its disadvantages are: (1) It requires the patient to have a special position, such as the Mecca position, which reduces the willingness of the patient to cooperate with the treatment, and it is even more difficult to treat comatose patients; (2) ) It is difficult to effectively reach the top of the nasal cavity, and the drug absorption rate is relatively low. Less than 1% of the drug can enter the central nervous system, which is a big waste; (3) Most of the drugs are absorbed into the peripheral circulation through the rich blood vessels in the nasal cavity, thus having Potential side effects may occur; (4) Most of the 100 μl drug per drop enters the upper airway with the respiratory airflow, and there is a possibility of upper airway obstruction for patients with swallowing reflex disappearance; (5) It can only be given to one nostril alternately, not at the same time. (6) It cannot be administered continuously, and the general administration time can only last for 20-30 minutes
[0004] Thin tube nasal drip method, this method uses a very thin PE tube, connects the syringe and sends the drug directly to the top of the nasal cavity, which effectively improves the defect that the traditional nasal drip method cannot effectively pass through the nasal cavity valve, but the defects of this method are: ( 1) if figure 1 The very thin tube can easily enter the pharynx through the lower nasal passage 3, especially for patients with lost gag reflex; and once the PE tube enters the lower nasal passage 3 by mistake, the drug will be exhaled or enter the lungs, or Most of the drugs are absorbed into the peripheral circulation through the rich blood vessels in the nasal cavity, which not only fails to achieve the therapeutic effect, but also has the possibility of potential side effects; (2) The very fine PE does not match the nasal cavity and has an effect on the nasal cavity; A large amount of drugs can be injected at one time, and a large amount of drugs cannot enter the central nervous system through the olfactory tract, but enter the upper respiratory tract; (4) can only be administered alternately, not at the same time, (5) cannot be administered continuously
[0005] Nasal spray, which uses the principle of mechanical spraying, sprays about 100 μl of medicine at a time, and can effectively enter the top of the nasal cavity. In addition, this method also avoids the disadvantage of poor tolerance of the thin tube administration method, but it still has considerable Defects: (1) A large amount of drugs injected each time cannot enter the center through the olfactory tract and enter the upper respiratory tract, and the efficiency is low; (2) can only be administered alternately, not at the same time, (3) cannot be administered continuously

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  • Double-nasal cavity continuous nasal administration device and using method thereof
  • Double-nasal cavity continuous nasal administration device and using method thereof
  • Double-nasal cavity continuous nasal administration device and using method thereof

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Embodiment Construction

[0024] Such as figure 2 It is a partial cross-sectional structure schematic diagram of a double nasal cavity continuous nasal drug delivery device, including an osmotic pump 3, a PE tube 2, a drug release head 1, a protective cover 4, and a three-way tube 5. The osmotic pump 3 passes through the three-way tube 5 and two PE tubes. The pipe 2 is connected, and the opposite ends of the two PE pipes 2 and the three-way pipe 5 are respectively connected with a drug release head 1. The drug release head 1 is in the shape of a forward taper, and there is a channel 6 in the drug release head 1 that communicates with the PE pipe 2. ; The protective cover 4 is an independent body, and is a truncated cone corresponding to the drug release head 1, and the minimum inner diameter of the lumen channel 7 is slightly larger than the maximum outer diameter of the drug release head 1, so that the drug release head 1 is easily inserted into the body. Sliding in the cavity channel 7, the protecti...

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Abstract

The invention discloses a double-nasal cavity continuous nasal administration device and a using method thereof. The device comprises an osmotic pump (3), PE pipes (2), a medicament releasing head (1), a protective sleeve (4) and a tee pipe (5), wherein the osmotic pump (3) is communicated with two PE pipes (2) through the tee pipe (5); opposite ends of the two PE pipes (2) and the tee pipe (5) are communicated with one medicament releasing head (1) respectively; the medicament releasing head (1) is regular cone-shaped and a passage (6) in the medicament releasing head (1) is communicated with the PE pipes (2); the protective sleeve (4) is an independent body and is a regular frustum body corresponding to the medicament releasing head (1); the minimal inner diameter of the inner cavity passage (7) of the protective sleeve (4) is slightly greater than the maximal outer diameter of the medicament releasing head (1), so that the medicament releasing head (1) can conveniently slide in the inner cavity passage (7); and the protective sleeve (4) is used for sealing the inferior nasal meatus of the nasal cavity of a human body. The device can realize continuous administration and double-nasal cavity administration and prevents a medicament releaser from entering the oropharynx. The using method is simple and convenient.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a dual-nasal continuous nasal drug delivery device and a use method thereof. Background technique [0002] Due to the existence of blood-brain barrier, etc., drugs cannot reach the central nervous system effectively through peripheral administration (oral, intravenous, etc.); although lateral ventricle administration can directly enter the central nervous system, due to its traumatic nature, it is greatly restricted in clinical application. limit. like figure 1 The intranasal structure diagram, nasal drug delivery can bypass the blood-brain barrier and directly reach the central nervous system 4 through the olfactory nerve 1 of the upper nasal cavity 3. At the same time, it has the characteristics of non-invasiveness, so it has a wide clinical application prospect . [0003] However, the current traditional nasal drug delivery method has great deficiencies, which lim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00
Inventor 刘新峰姜永军徐格林
Owner 刘新峰
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