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Furanodiene-containing medicinal composition, technology for preparing preparation thereof and medicinal use thereof

A technology of cyclodipene and composition of turmeric is applied in the field of pharmaceutical compositions containing cyclodiene of turmeric, can solve the problems of difficult drug absorption, poor stability, low bioavailability and the like, and achieves cost reduction, easy acceptance, The effect of increasing solubility and stability

Inactive Publication Date: 2013-11-06
HONGGUAN BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the compound is highly soluble in oily media, the emulsion or oil prepared by conventional methods has the disadvantages of easy precipitation and poor stability, especially when it enters the body. low disadvantage

Method used

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  • Furanodiene-containing medicinal composition, technology for preparing preparation thereof and medicinal use thereof
  • Furanodiene-containing medicinal composition, technology for preparing preparation thereof and medicinal use thereof
  • Furanodiene-containing medicinal composition, technology for preparing preparation thereof and medicinal use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: 1g Curcuma cyclodiene

[0031] 50g soybean oil

[0032] 10g soy lecithin

[0033] Add water for injection to the mark for a total of 1000ml

[0034] Preparation: first dissolve the emulsifier (soy phospholipid) in the oil phase (soybean oil), add the main drug Zedoary turmeric cyclodiene, stir to dissolve it, after stirring, filter with a 0.22μm microporous filter membrane for use. Add water for injection to the prescribed amount, homogenizer to make colostrum, and homogenizer to make the injection emulsion particle size. Sterile filtration through a 0.22μm microporous membrane, and finally filled in a 1ml dry sterile ampoule. An emulsion injection containing 1 mg of Zedoary turmeric cyclodiene per ampoule was prepared.

Embodiment 2

[0035] Example 2: 10 g zedoary turmeric cyclodiene, 50 g soybean oil, 20 g soybean phospholipid, and water for injection to the mark to a total of 1000 ml.

[0036] The method for preparing zedoary turmeric cyclodiene emulsion injection was the same as in Example 1, and an emulsion injection containing 10 mg of zedoary turmeric cyclodiene per ampoule was prepared.

Embodiment 3

[0037] Example 3: 40 g zedoary turmeric cyclodiene, 100 g corn oil, 20 g egg yolk lecithin, and water for injection to the mark to a total of 1000 ml.

[0038] The method for preparing zedoary turmeric cyclodiene emulsion injection was the same as that of Example 1, and an emulsion injection containing 40 mg of zedoary turmeric cyclodiene per ampoule was prepared.

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Abstract

The invention provides a furanodiene-containing medicinal composition with the administration frequency of once per day or less than once for treating or adjunctively treating malignancy. The composition is prepared into an injection administration preparation or an oral administration preparation, wherein the content of the furanodiene in the medicinal composition is 48 to 2,430mg. The preparation of the composition is preferably water-soluble injection, soft capsules, or tablets and hard capsules prepared through specific technology, and solves the problem that the conventional preparation is easy to separate out and is low in stability and bioavailability. The invention also provides application of the furanodiene-containing medicinal composition in preparing medicaments for treating or adjunctively treating the malignancy.

Description

Technical field [0001] The present invention relates to active ingredients of traditional Chinese medicines, pharmaceutical compositions, preparation methods and medical uses. Specifically, the present invention relates to a pharmaceutical composition containing curcuma cyclodiene, its preparation process and its medical use. Background technique [0002] Curcuma cyclodiene is a major component of turmeric oil, which was first reported by Hikiw in Japan, H et al. in 1968. Its chemical name is (5E, 9Z)-3,6,10-trimethyl-4,7,8,11-tetrahydroaryldecano[b]furan. [0003] The chemical structural formula is: [0004] [0005] The molecular formula is: C 15 H 20 O molecular weight: 216.15 [0006] At present, there have been reports on the application of zedoary turmeric cyclodiene in the treatment of tumor diseases, but there are no research reports on effective doses and systematic formulation prescription research reports. In addition, due to the extremely low water solubility of the comp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P35/00A61K9/08A61K9/66A61K9/48A61K9/20
Inventor 孟昭珂郭殿武吴耀东
Owner HONGGUAN BIO PHARMA CO LTD
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