Fast detector for ultra-trace disease markers

A marker and ultra-trace technology, applied in the field of biomedical detection, can solve problems such as inability to realize on-site rapid detection, difficulty in popularization and application, and high price of equipment, and achieve the effects of easy promotion, solving detection difficulties, and low cost

Active Publication Date: 2011-03-30
INST OF ELECTRONICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the detection of disease markers is mainly carried out in hospitals, using immune analyzers, which are operated by professionals. The equipment is huge and expensive, and the detection cost is high, so rapid on-site detection cannot be realized.
For community hospitals and rural areas, it is not easy to popularize and apply

Method used

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  • Fast detector for ultra-trace disease markers
  • Fast detector for ultra-trace disease markers
  • Fast detector for ultra-trace disease markers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] The heart failure marker BNP is detected by the ultra-trace disease marker rapid detector of the present invention.

[0034]After the detector is turned on, the semiconductor heating sheet 2 is started to heat the heating cup 1 through keyboard input, and the temperature sensor 3 detects the temperature of the heating cup 1 in real time. When the temperature rises from room temperature to close to 37°C, the heating control circuit 4 is controlled by the single-chip microcomputer to adjust the semiconductor heating plate 2, so that the temperature of the heating cup 1 rises steadily to 37°C and keeps 37°C constant. When temperature is too high or too low, regulate semiconductor heater 2 to come constant temperature. After the temperature of 37°C stabilizes, the detection control system 9 prompts to add detection reagents and samples. After the reagent to be detected and the sample are fully incubated within the time set by the detection control system 9, the reaction re...

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Abstract

The invention discloses a fast detector for ultra-trace disease markers, relating to a detection technology. The fast detector comprises a 37 DEG C constant-temperature heating system, a flow injection system and a detection control system, wherein in the 37 DEG C constant-temperature heating system, a temperature sensor detects a heating cup closely pressed by semiconductor heating sheets at real time, and continuously adjusts the semiconductor heating sheets to achieve the 37 DEG C constant-temperature heating function, thereby providing a 37 DEG C incubation environment for the biological reaction; a peristaltic pump is used for realizing flow injection and finishing automatic sampling so as to reduce human error and shorten detection time; the detection control system comprises a photoelectric conversion unit, a photon counting unit and a central processing and control unit; and a high-sensitive photomultiplier tube is used for realizing weak light detection, and the detection cavity is well shielded. By using the high-speed programmable logic device FPGA (field programmable gate array) to realize photon pulse counting, the invention has the advantages of random setting of counting time and counting digit capacity, sensitive counting and small error, thereby achieving the purpose of detecting ultra-trace substances.

Description

technical field [0001] The invention relates to the technical field of biomedical detection, and is an ultra-trace rapid detection instrument for disease markers, which can be used for the detection of disease markers capable of producing luminescent processes through specific reactions, and has broad application prospects in the field of medical detection. Background technique [0002] The content of many disease diagnostic markers is extremely low, and the matrix has many interferences and complex components, so it needs high-sensitivity ultra-trace analysis technology for detection. Common methods for ultra-trace detection include high-pressure liquid chromatography, capillary electrophoresis, and mass spectrometry. The operations are complex and time-consuming, and it is difficult to achieve rapid on-site detection. With the acceleration of the pace of life and the increase of life pressure, rapid detection of disease markers with high sensitivity and high specificity is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/08G01N21/76
Inventor 王蜜霞蔡新霞刘军涛刘儒平
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI
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