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Device for the preservation of a hepatic graft in normothermia

A technology for liver grafts and grafts, applied in the field of organ preservation equipment, can solve problems such as lack of technical feasibility, and achieve the effect of long storage time

Inactive Publication Date: 2011-05-18
私人诊所生物医学研究基金会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it is mentioned in the text that organs can be preserved at 37°C if the latter is not achieved, no specific system allows analysis of the technical feasibility of this alternative

Method used

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  • Device for the preservation of a hepatic graft in normothermia
  • Device for the preservation of a hepatic graft in normothermia

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Embodiment Construction

[0031] A preferred embodiment of the device for preserving a liver graft (1) object according to the invention is described below with reference to the accompanying drawings.

[0032] figure 1 The container (2) or chamber in which the liver graft (1) is contained for its preservation is shown. The container (2) can be opened to introduce the liver graft (1) and to perform cannulation. Once the liver graft (1) is introduced and the cannula is connected, the container (2) will be closed in a leak-tight manner.

[0033] The liver graft (1) inside the container (2) will be placed on the porous fibers (15), the liver graft (1) being immersed in the preservation solution. In a preferred embodiment the preservation solution may be blood, or a dilution of erythrocytes in serum.

[0034] The position of the liver graft (1) in the porous fiber (15) will be a position opposite to the normal position of the liver graft (1) in an erect human body. The part forming the upper end of the li...

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Abstract

The invention relates to a device for the preservation of a hepatic graft (1) in normothermia comprising a receptacle (2) in which said hepatic graft (1) is housed in a preservation solution, an arterial perfusion circuit (3), a portal perfusion circuit (5), at least one flow sensor (7) of a perfusion circuit, and at least one pressure sensor (8) of a perfusion circuit. For the purpose of increasing the preservation of the hepatic graft (1), the preservation device additionally comprises an arterial oxygenator (11) connected to the arterial perfusion circuit (3), a portal oxygenator (12) connected to the portal perfusion circuit (5), at least one arterial perfusion pump (9), at least one portal perfusion pump (10), a temperature exchange module (13) configured to maintain the temperature inside the receptacle (2) in normothermia, and a pressure and flow control device (14).

Description

technical field [0001] The present invention relates to the field of organ preservation devices for later transplantation or for sampling. More specifically, it relates to devices for preserving liver grafts at normal temperature, ie at body temperature similar to that of the human body. Background technique [0002] Liver transplantation is the only effective therapy for patients with advanced liver disease. However, it has a low utilization rate due to the shortage of transplanted organs. Between 10% and 30% of patients in the European Union and in the United States die while waiting for a suitable liver for transplant. [0003] The selection of a suitable donor is crucial to the success of liver transplantation. The purpose of evaluating liver donors is to identify those organs that have a high probability of functioning properly and to discard those organs that are foreseeable to fail. [0004] Use preservation methods such as the Wisconsin method to reduce the metab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
CPCA01N1/0247A01N1/02
Inventor 康斯坦丁诺·方德维拉坎波安琪尔·鲁伊斯阿兰斯胡安·卡洛斯·加西亚-瓦尔德卡萨斯萨尔加多
Owner 私人诊所生物医学研究基金会
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