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Venous retention needle suite with hirudin anticoagulation tube sealing device

A technology of intravenous indwelling needles and hirudin, which is applied in the field of medical devices, can solve the problems of cumbersome extraction steps of natural hirudin, limitations in research and clinical application, and difficulty in obtaining a sufficient amount of pure products, so as to reduce the risk of phlebitis and reduce the risk of medical treatment. The effects of preventing disputes and reducing the workload of nurses

Inactive Publication Date: 2011-12-14
天津百新生物技术研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the cumbersome extraction steps of natural hirudin, the difficulty of raising leeches, and the lack of sources of leeches, it is difficult to obtain a sufficient amount of pure products, which limits research and clinical applications.

Method used

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  • Venous retention needle suite with hirudin anticoagulation tube sealing device
  • Venous retention needle suite with hirudin anticoagulation tube sealing device
  • Venous retention needle suite with hirudin anticoagulation tube sealing device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] figure 1 It is a structural schematic diagram of the intravenous indwelling needle set with the hirudin anticoagulant blood sealing device of the present invention. Such as figure 1 As shown, the venous indwelling needle set with the hirudin anticoagulant blood sealing device of the present invention includes a sleeve 1 guided by a puncture needle 17 and inserted into the vein, and a transparent transparent plug 3 connected to the built-in isolation sealing plug 3 at the rear end of the sleeve 1. The tee 2 and the infusion connector 6 for connecting the infusion line or the blood collection line.

[0046] One end of the transparent tee 2 is connected to the casing 1 , one end is sealed by an isolation sealing plug 3 , and the third end is connected to the infusion joint 6 through the extension tube 4 . The cannula 1 is sleeved on the outside of the puncture needle 17 , and the tip of the puncture needle 17 protrudes from the front end of the cannula 1 . The rear end ...

Embodiment 2

[0053] comparative experiment

[0054] The concentration of hirudin is: 0.01mg / ml~50mg / ml, about 1ml-15ml for each use according to different needs.

[0055]

[0056]

[0057] The relationship between hirudin and coagulation factors is as follows:

[0058] First, recombinant hirudin and α-thrombin form a stable complex with equimolar non-covalent binding (the dissociation constant is very small, 0.8×10 -10 mol or 2.0×10 -14 mol). At this time, all protease hydrolysis functions of thrombin are blocked, so hirudin can not only prevent the coagulation of fibrinogen, but also block the hemostatic reaction catalyzed by thrombin, such as the activation of factors V, VIII and III and the thrombin-induced platelet The reaction prevents the generation of thrombin caused by the feedback of prothrombin activation. At the same time, hirudin does not interfere with the biosynthesis of coagulation factors, and has no effect on antithrombin III (AT-III).

[0059] Second, when hirud...

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Abstract

The invention provides a venous retention needle suite with a hirudin anticoagulation tube sealing device, which comprises a casing, a transparent tee joint and a transfusion joint, wherein the casing is guided by a puncture needle and inserted into a vein; the transparent tee joint is connected to a built-in isolated sealing plug at the rear end of the casing; the transfusion joint is connected with a transfusion tube or a blood taking tube; the transparent tee joint is connected with the transfusion joint by an extension tube; the transfusion joint is sealed by a sealed end cap; one end of the transparent tee joint connected with the extension tube forms a double-cavity joint; one end of the double-cavity joint is connected with the extension tube, and the other end of the double-cavityjoint is connected with a tube sealing device; and the tube sealing device comprises a liquid storing bag in a support and a roller which is arranged between the two side walls of the support and used for pushing the liquid in the liquid storing bag forwards. The venous retention needle suite with the hirudin anticoagulation tube sealing device can ensure that a tubular cavity of the retention needle is filled with the tube sealing liquid. The tube sealing liquid in the tube sealing device is hirudin diluent which has good anticoagulation effect and does not influence any index of serum test in blood.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to an intravenous indwelling needle set with a hirudin anticoagulant blood tube sealing device. Background technique [0002] In recent years, with the rapid development of medical science, intravenous indwelling needles that can reduce the pain of repeated punctures have been widely used in critically ill patients for rescue infusion, intravenous hypernutrition, and intermittent intravenous antibiotics or other drugs. Indwelling catheters include puncture needles and cannulas. After the puncture needle is inserted into the patient's vein with the cannula, the puncture needle is pulled out, the cannula remains in the body, and the outer end is connected to the infusion device or the blood collection device. The venous indwelling needle can not only be used for routine venous infusion, but also can be used for intermittent multiple blood collection, which not only avoids the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M5/158A61B5/153A61L31/04A61L31/02A61L31/06
Inventor 刘晨刘金雪
Owner 天津百新生物技术研发有限公司
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