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Method for preparing Shuxuening injection

A technology of injection and filtrate, applied in pharmaceutical formulations, cardiovascular system diseases, medical raw materials derived from Ginkgo biloba, etc., can solve the problems of unstable product quality, incomplete removal, poor solubility, etc., to achieve stable efficacy and avoid Degradation and good solubility

Active Publication Date: 2011-06-08
通化谷红制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Shuxuening Injection in the domestic market is produced by many companies, and their products have technical problems such as poor solubility and unstable product quality.
The main reason is that in the preparation process of Ginkgo biloba extract, some impurities such as protein, tannin and other ineffective components are not completely removed, and the solubility is not good. The breakthrough of the Shuxuening injection process of the present invention fundamentally solves the above problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of Ginkgo biloba extract: crush Ginkgo leaves, add 10 times the amount of 95% ethanol, soak at 40°C for 6 hours, concentrate to 1 / 5 of the volume of the extract, filter, add 2 times the amount of 95% ethanol, Refrigerate overnight, then add 2% concentrated amount of co-solvent for filtration, collect the filtrate and concentrate it to 5 times the column volume, adjust the pH value at 3, absorb it with a macroporous resin, desorb it with 60% ethanol solution, and use an ultra-thin filter with a cut-off molecular weight of 30,000 Membrane ultrafiltration to obtain ginkgo extract.

Embodiment 2

[0020] Preparation of ginkgo extract: crush ginkgo leaves, add 30 times the amount of 80% ethanol, soak at 50°C for 5 hours, concentrate to 1 / 6 of the volume of the extract, filter, add 2 times the amount of 95% ethanol, Refrigerate overnight, then add 3% concentrated amount of co-solvent for filtration, collect the filtrate and concentrate it to 15 times the column volume, adjust the pH value at 4, absorb it with a macroporous resin, desorb it with 65% ethanol solution, and use an ultra Membrane ultrafiltration to obtain ginkgo extract.

Embodiment 3

[0022] Preparation of ginkgo extract: crush ginkgo leaves, add 40 times the amount of 70% ethanol, soak at 60°C for 2 hours, concentrate to 1 / 7 of the volume of the extract, filter, add 3 times the amount of 95% ethanol, Refrigerate overnight, then add 3% concentrated amount of co-solvent for filtration, collect the filtrate and concentrate it to 17 times the column volume, adjust the pH value at 6, absorb it through macroporous resin, desorb it with 80% ethanol solution, and use super Membrane ultrafiltration to obtain ginkgo extract.

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PUM

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Abstract

The invention belongs to the field of medicinal preparations and particularly discloses a method for preparing a Shuxuening injection having the effects of expanding blood vessels and improving microcirculation. The preparation method comprises the following steps of: grinding ginkgo leaves and performing the technical treatments of the ginkgo leaves, such as ethanol soakage, condensation filtration, ethanol refrigeration, resin adsorption and ethanol elution, to obtain extracting solution of ginkgo. The method can guarantee that inactive substances such as proteins and tannins are completely eliminated, the degradation of active substances is avoided, related substances in the preparation are reduced, and the finished product of the preparation has the advantages of high stability, small irritability, high solubility and stable curative effect. Clinical tests prove that the Shuxuening injection can be used for intravenous drip to treat diseases such as ischemic cardiovascular and cerebrovascular diseases, coronary heart disease, angina, cerebral embolism, cerebrovascular spasm and the like.

Description

technical field [0001] The medicine belongs to the technical field of preparation methods of pharmaceutical preparations, specifically relates to a preparation method of Shuxuening injection, and more specifically relates to a small-capacity injection whose main component is ginkgo extract. Background technique [0002] Shuxuening Injection is a sterilized aqueous solution made from Ginkgo biloba extract. Ginkgo biloba is the dried leaf of Ginkgo biloba plant, which is a traditional Chinese medicinal material for promoting blood circulation and removing blood stasis. It has good pharmacological effects in treating cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, and hyperlipidemia. Ginkgo biloba extract contains effective components such as total flavonoids and total lactones, and total flavonoids are the main active components of Ginkgo biloba extract. The total flavonoids mainly exist in the form of glycosides in Ginkgo biloba extract, mai...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K9/08A61P3/06A61P9/10A61P11/00A61K127/00
Inventor 郭智华
Owner 通化谷红制药有限公司
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