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Serial Chinese medicinal preparation for treating child common cold and preparation process and quality control method thereof

A technology of traditional Chinese medicine preparations and children's colds, which is applied in the direction of medical formulas, drug combinations, respiratory diseases, etc., can solve the problems of loss of volatile oil and active ingredients, affect clinical curative effect, and affect curative effect, so as to reduce process and turnover and ensure clinical curative effect , the effect of shortening the production cycle

Active Publication Date: 2011-07-06
SHANDONG MINGREN FURUIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above conditions have seriously affected the clinical efficacy of this product
[0005] In addition, Chinese patent 200510088659.8 discloses a patent for Xiaoer Jiegan effervescent tablet and its preparation method. It only reformed the dosage form, but the volatile oil also adopts the spraying technology, and the granulation also adopts the traditional granulation technology, so it still exists Insufficient effect on curative effect due to loss of volatile oil and active ingredients

Method used

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  • Serial Chinese medicinal preparation for treating child common cold and preparation process and quality control method thereof
  • Serial Chinese medicinal preparation for treating child common cold and preparation process and quality control method thereof
  • Serial Chinese medicinal preparation for treating child common cold and preparation process and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Take 125 parts by weight of Campanulaceae and pulverize into fine powder; add 415 parts by weight of Bupleuri, add 6 times the amount of water, soak for 6 hours, distill and extract the volatile oil for 3 hours, collect the distilled volatile oil distillate and aqueous solution in another device; take the distillate of volatile oil, add β -Cyclodextrin (100ml:1g), stirred at 30°C for 4h, clathrate into clathrate; 830 parts by weight of medicinal residues and Folium baicalensis, 415 parts by weight of Scutellaria baicalensis, 415 parts by weight of Schizonepeta, 125 parts by weight of bellflower, 165 parts by weight of licorice Mix the parts by weight, add water to decoct twice, add 6 times the amount of water to decoct twice (3, 2 hours in sequence), combine the decoction and the distilled aqueous solution of Bupleurum radix, filter, and concentrate the filtrate until it is measured at 60-80°C. To obtain a concentrated solution with a relative density of 1.20-1.25, add e...

Embodiment 2

[0115] Take 125 parts by weight of Campanulaceae and pulverize into fine powder; add 415 parts by weight of Radix Bupleurum, add 6 times the amount of water, soak for 6 hours, distill and extract the volatile oil for 5 hours, collect the distilled volatile oil distillate and aqueous solution in another device; take the distillate of volatile oil, add β -Cyclodextrin (100ml: 6g), stirred at 60°C for 2h to form an inclusion compound; 830 parts by weight of medicinal residues and Folium baicalensis, 415 parts by weight of Scutellaria baicalensis, 415 parts by weight of Schizonepeta, 125 parts by weight of platycodon grandiflorum, 165 parts by weight of licorice Mix the parts by weight, add water to decoct twice, add 6 times the amount of water to decoct twice (3, 2 hours in sequence), combine the decoction and the distilled aqueous solution of Bupleurum radix, filter, and concentrate the filtrate until it is measured at 60-80°C. To obtain a concentrated solution with a relative de...

Embodiment 3

[0117] Take 125 parts by weight of Campanulaceae and pulverize into fine powder; add 415 parts by weight of Bupleurum, add 6 times the amount of water, soak for 6 hours, distill and extract the volatile oil for 5 hours, collect the distilled volatile oil and aqueous solution in another device; take the volatile oil, add β-cyclodextrin In aqueous solution (4%) (2g: 100ml), stirred at 30°C for 4h to form clathrates; 830 parts by weight of medicinal residues and Folium Folium, 415 parts by weight of Scutellaria baicalensis, 415 parts by weight of Schizonepeta, 125 parts by weight of Campanulaceae, Mix 165 parts by weight of licorice, add water to decoct twice, add 8 times the amount of water to decoct twice (3 and 2 hours in turn), combine the decoction and the distilled aqueous solution of Bupleurum radix, filter, and concentrate the filtrate to 60-80 The concentrated solution with a relative density of 1.20-1.25 was measured at ℃, added ethanol to make the alcohol content 70%, s...

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Abstract

The invention discloses a serial Chinese medicinal preparation for treating child common cold, a preparation process and a quality control method thereof. Preparations are characterized by being prepared from traditional Chinese medicines, namely indigowoad leaf, Chinese thorowax root, baical skullcap root, fineleaf schizonepeta herb, platycodon root and liquoric root as well as pharmaceutical excipients. The preparations have the effects of clearing away heat, relieving exterior syndromes, reducing inflammation and relieving cough, and are used for common cold and fever, headache and stuffed-up nose, cough and sneeze, and sore throat. Volatile oil from Chinese thorowax root is a material base of the 'defervescence' of the preparation, has the characteristic of quick defervescence, and is an active ingredient for treating exogenous fever of children; and the traditional preparation process is to adopt a way of spraying the volatile oil into the preparation, and the volatile oil is almost completely lost during the production and storage due to the low content of the volatile oil, so that the clinical therapeutic effect is seriously affected. In the preparation process, a beta-cyclodextrin inclusion technology is adopted for the inclusion of the volatile oil from Chinese thorowax root to ensure that a liquid medicine is solidified; and thus the loss of the volatile oil during the production and storage is reduced, and the stability of the medicine is improved and the clinical therapeutic effect of the medicine is ensured at the same time. In addition, the more perfect quality control method is used for ensuring the quality; meanwhile, the clinical medication formulation is also enriched, so that the clinical medication demand can be better met.

Description

1. Technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a preparation process and a quality control method of a series of traditional Chinese medicine preparations for treating infantile colds. 2. Background technology [0002] Infantile cold is one of modal childhood disease, shows according to the result of World Health Organization statistics, and cold occupies the first place in pediatric disease. Common symptoms of colds in children are fever, nasal congestion, runny nose, cough, etc., mainly fever, often high fever, and even convulsions; traditional Chinese medicine believes that children are in the process of growth and development, full of vitality and rapid development, but the viscera Delicate, lacking body energy, immature material bases such as essence, blood, body fluid and various physiological functions in the body; therefore, the resistance to diseases is poor, and children cannot adjust themse...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61P11/00G01N30/02G01N30/90
Inventor 凌沛学张玲吴维群贾美春张海立刘妍妍
Owner SHANDONG MINGREN FURUIDA PHARMA
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