The invention relates to a method and a system for estimation of population density and mobility based on multi-data fusion. The method comprises the steps of making a map of a monitoring area, combining with mobile terminal information, and establishing a mobile terminal information environment database; carrying out wireless positioning on the mobile terminal to obtain wireless data; carrying out population positioning on the monitoring area covered by video monitoring, and obtaining video monitoring data; and fusing the wireless data, the monitoring data and the monitoring data of other equipment in the monitoring area, and estimating the population number, the density, the distribution and the flowing tendency in the monitoring area. According to the method and the system, through setting of the mobile terminal information environment database, adoption of a wireless positioning mode and a video positioning mode, and combination with the mobile terminal information environment database, the wireless data and the video monitoring data are acquired, the data monitored by the other equipment in the monitoring area is matched, and the data in the three aspects can be fused, so thatpopulation mobility estimation is carried out through maximum utilization of the existing facilities, the estimation accuracy is high, and the application range is wide.