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Venous indwelling needle with hirudin anticoagulation pipe-sealing device

A technology of intravenous indwelling needles and hirudin, which is applied in the field of medical devices, can solve the problems of cumbersome extraction steps of natural hirudin, difficulty in obtaining a sufficient amount of pure products, and limitations in research and clinical application, so as to reduce the risk of phlebitis and reduce the risk of medical treatment. The effects of preventing disputes and reducing the workload of nurses

Inactive Publication Date: 2011-12-28
天津百新生物技术研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the cumbersome extraction steps of natural hirudin, the difficulty of raising leeches, and the lack of sources of leeches, it is difficult to obtain a sufficient amount of pure products, which limits research and clinical applications.

Method used

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  • Venous indwelling needle with hirudin anticoagulation pipe-sealing device
  • Venous indwelling needle with hirudin anticoagulation pipe-sealing device
  • Venous indwelling needle with hirudin anticoagulation pipe-sealing device

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] figure 1 It is a structural schematic diagram of the intravenous indwelling needle with the hirudin anticoagulant blood sealing device of the present invention. Such as figure 1 As shown, the venous indwelling needle with hirudin anticoagulant blood sealing device of the present invention comprises a cannula 1 inserted into the vein guided by a puncture needle 17, a transparent three-piece transparent plug 3 connected to a built-in isolation sealing plug 3 at the rear end of the cannula 1. 2 and the infusion connector 6 for connecting the infusion line or blood collection line.

[0046] One end of the transparent tee 2 is connected to the casing 1 , one end is sealed by an isolation sealing plug 3 , and the third end is connected to the infusion joint 6 through the extension tube 4 . The extension tube 4 is provided with a liquid stop card 5 . The cannula 1 is sleeved on the outside of the puncture needle 17 , and the tip of the puncture needle 17 protrudes from the ...

Embodiment 2

[0053] comparative experiment

[0054] The concentration of hirudin is: 0.01mg / ml~50mg / ml, about 1ml-15ml for each use according to different needs.

[0055]

[0056] The relationship between hirudin and coagulation factors is as follows:

[0057] First, recombinant hirudin and α-thrombin form a stable complex with equimolar non-covalent binding (the dissociation constant is very small, 0.8×10 -10 mol or 2.0×10 -14 mol). At this time, all protease hydrolysis functions of thrombin are blocked, so hirudin can not only prevent the coagulation of fibrinogen, but also block the hemostatic reaction catalyzed by thrombin, such as the activation of factors V, VIII and III and the thrombin-induced platelet The reaction prevents the generation of thrombin caused by the feedback of prothrombin activation. At the same time, hirudin does not interfere with the biosynthesis of coagulation factors and has no effect on antithrombin III (AT-III).

[0058] Second, when hirudin, disulfide...

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Abstract

The invention discloses a venous indwelling needle with a hirudin anticoagulation pipe-sealing device. The venous indwelling needle comprises a cannula which is led by a puncture needle and then inserted into a vein, a transparent tee joint which is connected with the rear end of the cannula and has a built-in isolating sealing plug, and a transfusion joint used for connecting a transfusion pipe or a blood-sampling pipe. The transparent tee joint is connected with the transfusion joint through an extension pipe. The transfusion joint is sealed by a sealing end cap. A crotch is formed on the end, which is connected with the extension pipe, of the transparent tee joint. The other end of the crotch is connected with a pipe-sealing device. The pipe-sealing device comprises a liquid-storing bag arranged in a support and a roller arranged between the two side walls of the support and used for pushing the liquid in the liquid-storing bag forward. By the invention, a pipe cavity of the indwelling needle can be filled with the pipe-sealing liquid. The pipe-sealing liquid in the pipe-sealing device can be hirudin diluent, which has good anticoagulant function and does not influence the indexes for the test of blood serum.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to an intravenous indwelling needle with a hirudin anticoagulant blood tube sealing device. Background technique [0002] In recent years, with the rapid development of medical science, intravenous indwelling needles that can reduce the pain of repeated punctures have been widely used in critically ill patients for rescue infusion, intravenous hypernutrition, and intermittent intravenous antibiotics or other drugs. Indwelling catheters include puncture needles and cannulas. After the puncture needle is inserted into the patient's vein with the cannula, the puncture needle is pulled out, the cannula remains in the body, and the outer end is connected to the infusion device or the blood collection device. The venous indwelling needle can not only be used for routine venous infusion, but also can be used for intermittent multiple blood collection, which not only avoids the pai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/153A61L31/04A61L31/02A61L31/06
Inventor 刘晨刘金雪
Owner 天津百新生物技术研发有限公司
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