Medicine composite used for curing endometriosis, preparation method and applications thereof
A technology for endometriosis and ectopic disease, applied in the field of medicine, can solve the problems of harming the physical and mental health of patients, large side effects, unsatisfactory treatment effect, etc., and achieve the effect of good treatment effect.
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Embodiment 1
[0015] The investigation of embodiment 1 extraction technology
[0016] Formulated by weight astragalus, sage vine, evodia, mugwort leaves, chuanxiong, zedoary, ground beetle, red peony, leech, Patrinia, dandelion, cork and honeysuckle (10:10:5:5:4:4:5: 5:5:10:10:5:10) Weigh 264g (4 parts) of medicinal materials, add 10 times the amount of 30%, 60%, 75%, 90% ethanol to soak for 30 minutes, heat and reflux extraction twice, each After 2 hours, the filtrates were combined and concentrated to 500ml. The sample solution was taken to pass through the microporous membrane, and the content of evodiamine was determined according to the proposed content determination method. Three parallel operations were performed. The results are shown in Table 1.
[0017] Table 1 Examination results of extraction solvents (n=3)
[0018]
[0019] It can be known from Table 1-6 that the content of Evodia rutaecarpa extracted with 75% ethanol is relatively high among the four extraction solvent...
Embodiment 2
[0034] The investigation of embodiment 2 purification process
[0035] Weigh 1000g of medicinal materials according to the formula described in Example 1, add 12 times the amount of 75% ethanol to reflux extraction for 3 times, each time for 2 hours, filter, combine the extracts, recover ethanol under reduced pressure to obtain alcohol extract I; D101 macroporous resin was applied to a part of solution I, and the effluent was eluted with water until the effluent was colorless, then eluted with 75% ethanol until the effluent was colorless, and then eluted with 90% ethanol until colorless, to obtain ethanol eluent II; Concentrate the alcohol extract Ⅰ to an appropriate amount (relative density is 1.02-1.05), centrifuge to obtain centrifugal precipitate Ⅲ and extract Ⅳ; put D101 macroporous resin on the extract Ⅳ, elute with water until the effluent is colorless, and then wash with Elute with 75% ethanol until the effluent is colorless, and then elute with 90% ethanol to obtain...
Embodiment 3
[0048] The investigation of embodiment 3 formula dosage forms
[0049] In the clinical application of this formula, enema is used after extraction, and the drug is closer to the treatment site, and the curative effect is better. Therefore, in combination with the clinical medication method and the best therapeutic effect, the rectal suppository is selected as the dosage form of this formula.
[0050] In order to ensure that the active ingredients in the extract are less damaged or damaged, the ethanol eluate is concentrated under reduced pressure. The extract is dried by vacuum drying.
[0051] Adopt hot-melt method to prepare suppository, its concrete method is as follows:
[0052] 1) The technological process of the hot melt method is: melting matrix - adding medicine (mixing) - injection molding - cooling - scraping - taking out - finished suppository.
[0053] 2) The screening of the matrix is as follows: select three representative matrices of glycerin gelatin, PEG4...
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