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Medicinal evodia fruit lactone and polysaccharide extracts for treating digestive tract diseases, and preparation method and application thereof

A technique for evodiolide and digestive tract diseases, which is applied in the field of evodiolide and polysaccharide extract for treating digestive tract diseases and the fields of preparation and use thereof, can solve the problem of low content, insufficient to explain the clinical effect of evodia, and insufficient medicinal substances of evodia Thoroughness etc.

Active Publication Date: 2011-08-03
匡海学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the chemical constituents of Evodia rutaecarpa mainly focuses on the alkaloids, flavonoids, volatile oils, and tannins in Evodia rutaecarpa, but the content of these components is low in Evodia rutaecarpa, which is not enough to explain the clinical effects of Evodia rutaecarpa. Effective material basis research is not thorough enough
The polysaccharide extract has a large content and has no toxic side effects, but the research on polysaccharides is almost blank

Method used

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  • Medicinal evodia fruit lactone and polysaccharide extracts for treating digestive tract diseases, and preparation method and application thereof
  • Medicinal evodia fruit lactone and polysaccharide extracts for treating digestive tract diseases, and preparation method and application thereof
  • Medicinal evodia fruit lactone and polysaccharide extracts for treating digestive tract diseases, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 4kg of Evodia edulis medicinal material dried to constant weight, extract with 10 times 90% ethanol at reflux for 3 times, 3h each time, filter with linen cloth, dry the filter residue in a ventilated place, add 10 times the amount of distilled water to the residue, reflux for extraction 3 times, 3 hours each time, filter with linen cloth, combine the filtrate, recover the solvent under reduced pressure to 1 times the volume of the medicinal material, adjust to 85% alcohol content with 100% ethanol, let stand overnight, centrifuge at 2000 rpm every minute, and precipitate sequentially Wash with 3 times the amount of absolute ethanol and acetone to obtain a precipitate. Take the precipitate and add distilled water to reconstitute it, and the molecular weight range is 3.0×10 3 -1.2×10 4 Dialysis with flowing water in a dialysis bag for 48 hours, and distilled water for 72 hours. The dialysate is freeze-dried to obtain crude polysaccharides; after passing through DEAE-S...

Embodiment 2

[0021] Take the alcohol extract in the above example 1, concentrate the alcohol extract to 0.5 volume of medicinal materials under reduced pressure, add 1 volume of water to the thick paste to disperse, and apply AB-8 type macroporous resin to the column layer of the dispersed thick paste After analysis, gradient elution was performed with distilled water, 30%, 50%, 70%, 95% ethanol, and the eluent with 50%-95% ethanol concentration was collected, and the solvent was recovered to obtain the evodia lactone extract. The content accounts for more than 50% of the total weight percentage of the extract.

Embodiment 3

[0022] Example 3 Preparation of oral liquid:

[0023] Take 275g of evodia edulis polysaccharide extract and 25g of evodia lactones extract, add an appropriate amount of solubilizer, grind, dilute with a small amount of water, mix, then add correctives and preservatives, mix, and add water to the specified amount. Mix well, divide into 1000 pieces, 10ml / piece, sterilize, and get ready.

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Abstract

The invention discloses an active ingredient oral liquid of medicinal evodia fruit, which is used for treating digestive tract diseases such as gastric ulcer, duodenal ulcer, gastritis, cholecystitis, pancreatitis, enteritis and the like. The extract consists of a medicinal evodia fruit polysaccharide extract and a medicinal evodia fruit lactone extract. The invention also discloses a preparation method of the medicinal evodia fruit polysaccharide extract and the medicinal evodia fruit lactone extract. Based on glucose, the content of medicinal evodia fruit polysaccharides is over 68 weight percent of the medicinal evodia fruit polysaccharide extract, and the content of medcinal evodia fruit lactones is over 50 weight percent of the medicinal evodia fruit lactone extract. A large number of pharmacological experiments show that the medicinal evodia fruit polysaccharide extract and the medicinal evodia fruit lactone extract have the effects of treating the digestive tractdiseases such as the gastric ulcer, the duodenal ulcer, the gastritis, the cholecystitis, the pancreatitis, the enteritis and the like, and can be prepared into medicaments of various formulations or can be used as raw material medicaments in a mode of compatible combination.

Description

Technical field [0001] The present invention relates to an extract of the effective components of Evodia fructus in the treatment of gastric ulcer, duodenal ulcer, gastritis, cholecystitis, pancreatitis, enteritis and other gastrointestinal diseases, and in particular to an extract of the effective ingredients of evodia lactone and evodia fructus polysaccharide and a preparation method thereof The present invention also relates to a combination of evodia lactone and evodia fructus polysaccharide extract alone or in combination to prepare various clinical preparations to treat gastric ulcer, duodenal ulcer, gastritis, cholecystitis, pancreatitis, enteritis and other digestive tract diseases Medical use. Background technique [0002] Evodia is the dry and nearly mature fruit of Evodia rutaecarpa (Juss.) Benth.var bod-inieri (Dode) Huang. The nature and flavor are pungent, bitter, hot, with small toxicity, which is attributed to the liver, spleen, stomach and kidney meridians. It ...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P1/00A61P1/04A61P1/16A61P1/18
Inventor 匡海学杨炳友孟永海夏永刚杨志欣宋佳欣
Owner 匡海学
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