Oil in water type blumea oil nanoemulsion and preparation method thereof
An oil-in-water type, artemisia argyi oil technology, which is applied in the directions of botanical equipment and methods, pharmaceutical formulations, emulsion delivery, etc., can solve the problems of unstable product physical properties, volatile argyi essential oil, and low availability, etc. The effect of bioavailability, good wettability and simple preparation method
Inactive Publication Date: 2011-08-31
NORTHWEST A & F UNIV
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Problems solved by technology
[0007] At present, the main products of mugwort oil are mugwort essential oil and mugwort oil capsules. Mugwort essential oil is volatile, and the physical properties of the product are unstable. It is difficult to preserve and disperse in water, and its utilization is not high.
Although mugwort leaf oil capsules can improve stability and bioavailability, it is inconvenient to take for people who have difficulty swallowing
Method used
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Experimental program
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Embodiment 1
[0053] Embodiment 1 preparation liquid concentration is the Artemisia argyi leaf oil nanoemulsion of 0.01%
[0054]
[0055] The sum of the mass of the above raw materials is 100g
[0056] The specific operation steps are:
[0057] 1) First, the Artemisia argyi oil is completely dissolved in the co-surfactant;
[0058] 2) add surfactant and mix well, set aside;
[0059] 3) Slowly add distilled water dropwise to the solution prepared in step 2), and keep stirring while adding dropwise, until a uniform and transparent system is formed.
Embodiment 3
[0062] Embodiment 3 preparation liquid concentration is 1.5% mugwort leaf oil nanoemulsion
[0063]
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The invention discloses an oil in water type blumea oil nanoemulsion. The particle size of the nanoemulsion is 1-100 nm, and the nanoemulsion is prepared by ingredients according to the following percentage: 0.01%-13.2% of blumea oil, 24%-36% of surfactant, 7.1%-16.5% of cosurfactant, 0-4.2% of oil phase, and the balance of distilled water, wherein the sum of the mass percentage of the raw materials is 100%. The blumea oil nanoemulsion has the effects of relieving a cough, eliminating sputum, easing pain, diminishing inflammation, resisting bacteria, and expelling midge and parasite, and the characteristics of low viscosity, good stability, strong dispersibility, quick absorption and the like, and the availability of the blumea oil nanoemulsion can be improved. The blumea oil nanoemulsion is simple in preparation process, low in energy consumption and toxicity, and high in security, and mass production of the blumea oil nanoemulsion can be realized without special equipment.
Description
technical field [0001] The invention belongs to the fields of medicine and daily chemical industry, and relates to a new dosage form of mugwort leaf oil with the functions of relieving cough, eliminating phlegm, analgesia, anti-inflammatory, antibacterial, mosquito repelling and insect repelling, and in particular to an oil-in-water type mugwort leaf oil nano Milk and methods for its preparation. Background technique [0002] Artemisia argyi is the dry leaf of Artemisia argyi, a plant in the Compositae family. It has the functions of relieving asthma and relieving cough, eliminating phlegm, anti-allergy and hemostasis, anti-coagulation, protecting liver and gallbladder, antipyretic and sedative, inhibiting cardiac contraction and lowering blood pressure. It is a commonly used Chinese medicinal material in clinical practice. . [0003] First of all, the volatile oil of Artemisia argyi leaves has the functions of antitussive, asthmatic and expectorant. The main active ingredi...
Claims
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IPC IPC(8): A61K36/282A61K8/97A61K9/107A01N65/12A23L3/3472A01P3/00A01P17/00A61P1/16A61P7/02A61P9/00A61P9/12A61P11/06A61P11/10A61P11/14A61P29/00A61P31/04A61P35/00A61P37/04A61P37/08A61Q17/02A61K127/00
Inventor 欧阳五庆王璟李雅
Owner NORTHWEST A & F UNIV